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10.3390/v14010039 http://scihub22266oqcxt.onion/10.3390/v14010039 35062243!8777766!35062243     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Viruses 2021 ; 14 (1): ä Nephropedia Template TP {{tp|p=35062243|t=2021. COVID-19: Multiorgan Dissemination of SARS-CoV-2 Is Driven by Pulmonary Factors |pdf=|usr=}}{{35062243}} gab.com Text COVID-19: Multiorgan Dissemination of SARS-CoV-2 Is Driven by Pulmonary Factors JO: Viruses http://www.kidney.de/pget.php?&tw=1&pmid=35062243 #FOAvip Multi-organ failure is one of the common causes of fatal outcome in COVID-19 patients. However, the pathogenetic association of the SARS-CoV-2 viral load (VL) level with fatal dysfunctions of the lungs, liver, kidneys, heart, spleen and brain, as well as with the risk of death in COVID-19 patients remains poorly understood. SARS-CoV-2 VL in the lungs, heart, liver, kidneys, brain, spleen and lymph nodes have been measured by RT qPCR using the following formula: N(SARS-CoV-2)/N(ABL1 x) 100. Dissemination of SARS-CoV-2 in 30.5% of cases was mono-organ, and in 63.9% of cases, it was multi-organ. The average SARS-CoV-2 VL in the exudative phase of diffuse alveolar damage (DAD) was 60 times higher than in the proliferative phase. The SARS-CoV-2 VL in the lungs ranged from 0 to 250,281 copies. The "pulmonary factors" of SARS-CoV-2 multi-organ dissemination are the high level of SARS-CoV-2 VL (>/=4909) and the exudative phase of DAD. The frequency of SARS-CoV-2 dissemination to lymph nodes was 86.9%, heart-56.5%, spleen-52.2%, liver-47.8%, kidney-26%, and brain-13%. We found no link between the SARS-CoV-2 VL level in the liver, kidneys, and heart and the serum level of CPK, LDH, ALP, ALT, AST and Cr of COVID-19 patients. Isolated detection of SARS-CoV-2 RNA in the myocardium of COVID-19 patients who died from heart failure is possible. The pathogenesis of COVID-19-associated multi-organ failure requires further research in a larger cohort of patients. Twit Text FOAVip COVID-19: Multiorgan Dissemination of SARS-CoV-2 Is Driven by Pulmonary Factors ????Viruses http://www.kidney.de/pget.php?&tw=1&pmid=35062243 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35062243 #FOAvip English Wikipedia <ref>{{Cite pmid|35062243}}</ref> COVID-19: Multiorgan Dissemination of SARS-CoV-2 Is Driven by Pulmonary Factors #MMPMID35062243 Odilov A; Volkov A; Abdullaev A; Gasanova T; Lipina T; Babichenko I Viruses 2021[Dec]; 14 (1): ä PMID35062243show ga Multi-organ failure is one of the common causes of fatal outcome in COVID-19 patients. However, the pathogenetic association of the SARS-CoV-2 viral load (VL) level with fatal dysfunctions of the lungs, liver, kidneys, heart, spleen and brain, as well as with the risk of death in COVID-19 patients remains poorly understood. SARS-CoV-2 VL in the lungs, heart, liver, kidneys, brain, spleen and lymph nodes have been measured by RT qPCR using the following formula: N(SARS-CoV-2)/N(ABL1 x) 100. Dissemination of SARS-CoV-2 in 30.5% of cases was mono-organ, and in 63.9% of cases, it was multi-organ. The average SARS-CoV-2 VL in the exudative phase of diffuse alveolar damage (DAD) was 60 times higher than in the proliferative phase. The SARS-CoV-2 VL in the lungs ranged from 0 to 250,281 copies. The "pulmonary factors" of SARS-CoV-2 multi-organ dissemination are the high level of SARS-CoV-2 VL (>/=4909) and the exudative phase of DAD. The frequency of SARS-CoV-2 dissemination to lymph nodes was 86.9%, heart-56.5%, spleen-52.2%, liver-47.8%, kidney-26%, and brain-13%. We found no link between the SARS-CoV-2 VL level in the liver, kidneys, and heart and the serum level of CPK, LDH, ALP, ALT, AST and Cr of COVID-19 patients. Isolated detection of SARS-CoV-2 RNA in the myocardium of COVID-19 patients who died from heart failure is possible. The pathogenesis of COVID-19-associated multi-organ failure requires further research in a larger cohort of patients. |Aged[MESH] |Aged, 80 and over[MESH] |Autopsy[MESH] |COVID-19/pathology/*virology[MESH] |Female[MESH] |Humans[MESH] |Lung/pathology/*virology[MESH] |Male[MESH] |Middle Aged[MESH] |Multiple Organ Failure/pathology/*virology[MESH] |RNA, Viral/genetics[MESH] |SARS-CoV-2/genetics/isolation & purification/metabolism/*pathogenicity[MESH] |Viral Load[MESH]COVID-19: Multiorgan Dissemination of SARS-CoV-2 Is Driven by Pulmonar(epmc).pdf DeepDyve Pubget Overpricing