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10.3389/fimmu.2021.785599 http://scihub22266oqcxt.onion/10.3389/fimmu.2021.785599 35058926!8763690!35058926     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2021 ; 12 (ä): 785599 Nephropedia Template TP {{tp|p=35058926|t=2021. Hypozincemia in COVID-19 Patients Correlates With Stronger Antibody Response |pdf=|usr=}}{{35058926}} gab.com Text Hypozincemia in COVID-19 Patients Correlates With Stronger Antibody Response JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=35058926 #FOAvip Zinc ion as an enzyme cofactor exhibits antiviral and anti-inflammatory activity during infection, but circulating zinc ion level during Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection is unclear. This study aimed to evaluate serum zinc ion level in Coronavirus Disease 2019 (COVID-19) patients and healthy subjects, as well as its correlation with antibodies against SARS-CoV-2. 114 COVID-19 patients and 48 healthy subjects (38 healthy volunteers and 10 close contacts of patients with COVID-19) were included. Zinc ion concentration and levels of antibodies against SARS-CoV-2 Spike 1 + Spike 2 proteins, nucleocapsid protein, and receptor-binding domain in serum were measured. Results showed that the concentration of zinc ion in serum from COVID-19 patients [median: 6.4 nmol/mL (IQR 1.5 - 12.0 nmol/mL)] were significantly lower than that from the healthy subjects [median: 15.0 nmol/mL (IQR 11.9 - 18.8 nmol/mL)] (p < 0.001) and the difference remained significant after age stratification (p < 0.001) or when the patients were at the recovery stage (p < 0.001). Furthermore, COVID-19 patients with more severe hypozincemia showed higher levels of IgG against the receptor-binding domain of SARS-CoV-2 spike protein. Further studies to confirm the effect of zinc supplementation on improving the outcomes of COVID-19, including antibody response against SARS-CoV-2, are warranted. Twit Text FOAVip Hypozincemia in COVID-19 Patients Correlates With Stronger Antibody Response ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=35058926 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35058926 #FOAvip English Wikipedia <ref>{{Cite pmid|35058926}}</ref> Hypozincemia in COVID-19 Patients Correlates With Stronger Antibody Response #MMPMID35058926 Xu W; Liu Y; Zou X; Luo H; Wu W; Xia J; Chan MTV; Fang S; Shu Y; Wu WKK; Zhang L Front Immunol 2021[]; 12 (ä): 785599 PMID35058926show ga Zinc ion as an enzyme cofactor exhibits antiviral and anti-inflammatory activity during infection, but circulating zinc ion level during Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection is unclear. This study aimed to evaluate serum zinc ion level in Coronavirus Disease 2019 (COVID-19) patients and healthy subjects, as well as its correlation with antibodies against SARS-CoV-2. 114 COVID-19 patients and 48 healthy subjects (38 healthy volunteers and 10 close contacts of patients with COVID-19) were included. Zinc ion concentration and levels of antibodies against SARS-CoV-2 Spike 1 + Spike 2 proteins, nucleocapsid protein, and receptor-binding domain in serum were measured. Results showed that the concentration of zinc ion in serum from COVID-19 patients [median: 6.4 nmol/mL (IQR 1.5 - 12.0 nmol/mL)] were significantly lower than that from the healthy subjects [median: 15.0 nmol/mL (IQR 11.9 - 18.8 nmol/mL)] (p < 0.001) and the difference remained significant after age stratification (p < 0.001) or when the patients were at the recovery stage (p < 0.001). Furthermore, COVID-19 patients with more severe hypozincemia showed higher levels of IgG against the receptor-binding domain of SARS-CoV-2 spike protein. Further studies to confirm the effect of zinc supplementation on improving the outcomes of COVID-19, including antibody response against SARS-CoV-2, are warranted. |*Immunity[MESH] |Adult[MESH] |Antibodies, Viral/*blood/immunology[MESH] |COVID-19/*blood/*immunology/virology[MESH] |Case-Control Studies[MESH] |Cations, Divalent/blood[MESH] |Coronavirus Nucleocapsid Proteins/immunology[MESH] |Female[MESH] |Humans[MESH] |Immunoglobulin G/blood/immunology[MESH] |Male[MESH] |Middle Aged[MESH] |Phosphoproteins/immunology[MESH] |Protein Domains/immunology[MESH] |Real-Time Polymerase Chain Reaction/methods[MESH] |Retrospective Studies[MESH] |Reverse Transcriptase Polymerase Chain Reaction/methods[MESH] |SARS-CoV-2/genetics/*immunology[MESH] |Spike Glycoprotein, Coronavirus/immunology[MESH]Hypozincemia in COVID-19 Patients Correlates With Stronger Antibody Re(epmc).pdf DeepDyve Pubget Overpricing