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10.1126/sciadv.abi6110 http://scihub22266oqcxt.onion/10.1126/sciadv.abi6110 35050692!ä!35050692 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Adv 2022 ; 8 (8): eabi6110 Nephropedia Template TP {{tp|p=35050692|t=2022. Cannabidiol inhibits SARS-CoV-2 replication through induction of the host ER stress and innate immune responses |pdf=|usr=}}{{35050692}} gab.com Text Cannabidiol inhibits SARS-CoV-2 replication through induction of the host ER stress and innate immune responses JO: Sci Adv http://www.kidney.de/pget.php?&tw=1&pmid=35050692 #FOAvip The spread of SARS-CoV-2 and ongoing COVID-19 pandemic underscores the need for new treatments. Here we report that cannabidiol (CBD) inhibits infection of SARS-CoV-2 in cells and mice. CBD and its metabolite 7-OH-CBD, but not THC or other congeneric cannabinoids tested, potently block SARS-CoV-2 replication in lung epithelial cells. CBD acts after viral entry, inhibiting viral gene expression and reversing many effects of SARS-CoV-2 on host gene transcription. CBD inhibits SARS-CoV-2 replication in part by up-regulating the host IRE1alpha RNase endoplasmic reticulum (ER) stress response and interferon signaling pathways. In matched groups of human patients from the National COVID Cohort Collaborative, CBD (100 mg/ml oral solution per medical records) had a significant negative association with positive SARS-CoV-2 tests. This study highlights CBD as a potential preventative agent for early-stage SARS-CoV-2 infection and merits future clinical trials. We caution against use of non-medical formulations including edibles, inhalants or topicals as a preventative or treatment therapy at the present time. Twit Text FOAVip Cannabidiol inhibits SARS-CoV-2 replication through induction of the host ER stress and innate immune responses ????Sci Adv http://www.kidney.de/pget.php?&tw=1&pmid=35050692 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35050692 #FOAvip English Wikipedia <ref>{{Cite pmid|35050692}}</ref> Cannabidiol inhibits SARS-CoV-2 replication through induction of the host ER stress and innate immune responses #MMPMID35050692 Nguyen LC; Yang D; Nicolaescu V; Best TJ; Gula H; Saxena D; Gabbard JD; Chen SN; Ohtsuki T; Friesen JB; Drayman N; Mohamed A; Dann C; Silva D; Robinson-Mailman L; Valdespino A; Stock L; Suarez E; Jones KA; Azizi SA; Demarco JK; Severson WE; Anderson CD; Millis JM; Dickinson BC; Tay S; Oakes SA; Pauli GF; Palmer KE; Meltzer DO; Randall G; Rosner MR Sci Adv 2022[Feb]; 8 (8): eabi6110 PMID35050692show ga The spread of SARS-CoV-2 and ongoing COVID-19 pandemic underscores the need for new treatments. Here we report that cannabidiol (CBD) inhibits infection of SARS-CoV-2 in cells and mice. CBD and its metabolite 7-OH-CBD, but not THC or other congeneric cannabinoids tested, potently block SARS-CoV-2 replication in lung epithelial cells. CBD acts after viral entry, inhibiting viral gene expression and reversing many effects of SARS-CoV-2 on host gene transcription. CBD inhibits SARS-CoV-2 replication in part by up-regulating the host IRE1alpha RNase endoplasmic reticulum (ER) stress response and interferon signaling pathways. In matched groups of human patients from the National COVID Cohort Collaborative, CBD (100 mg/ml oral solution per medical records) had a significant negative association with positive SARS-CoV-2 tests. This study highlights CBD as a potential preventative agent for early-stage SARS-CoV-2 infection and merits future clinical trials. We caution against use of non-medical formulations including edibles, inhalants or topicals as a preventative or treatment therapy at the present time. |A549 Cells[MESH] |Animals[MESH] |Antiviral Agents/chemistry/*pharmacology[MESH] |COVID-19 Drug Treatment[MESH] |COVID-19/virology[MESH] |Cannabidiol/chemistry/metabolism/*pharmacology[MESH] |Chlorocebus aethiops[MESH] |Endoplasmic Reticulum Stress/drug effects[MESH] |Endoribonucleases/genetics/metabolism[MESH] |Epithelial Cells/virology[MESH] |Female[MESH] |Gene Expression Regulation, Viral/drug effects[MESH] |Host-Pathogen Interactions/*drug effects/physiology[MESH] |Humans[MESH] |Immunity, Innate/*drug effects[MESH] |Interferons/metabolism[MESH] |Mice[MESH] |Protein Serine-Threonine Kinases/genetics/metabolism[MESH] |SARS-CoV-2/*drug effects/physiology[MESH] |Vero Cells[MESH] |Virus Internalization/drug effects[MESH]Cannabidiol inhibits SARS-CoV-2 replication through induction of the h(epmc).pdf DeepDyve Pubget Overpricing