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10.1155/2022/5397733

http://scihub22266oqcxt.onion/10.1155/2022/5397733
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35047106!8762758!35047106
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suck abstract from ncbi


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pmid35047106      Oxid+Med+Cell+Longev 2022 ; 2022 (ä): 5397733
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  • Superoxide Dismutase Prevents SARS-CoV-2-Induced Plasma Cell Apoptosis and Stabilizes Specific Antibody Induction #MMPMID35047106
  • Mo LH; Luo XQ; Ma K; Shao JB; Zhang GH; Liu ZG; Liu DB; Zhang HP; Yang PC
  • Oxid Med Cell Longev 2022[]; 2022 (ä): 5397733 PMID35047106show ga
  • The infection of coronavirus disease (COVID-19) seriously threatens human life. It is urgent to generate effective and safe specific antibodies (Abs) against the pathogenic elements of COVID-19. Mice were immunized with SARS-CoV-2 spike protein antigens: S ectodomain-1 (CoV, in short) mixed in Alum adjuvant for 2 times and boosted with CoV weekly for 6 times. A portion of mice were treated with Maotai liquor (MTL, in short) or/and heat stress (HS) together with CoV boosting. We observed that the anti-CoV Ab was successfully induced in mice that received the CoV/Alum immunization for 2 times. However, upon boosting with CoV, the CoV Ab production diminished progressively; spleen CoV Ab-producing plasma cell counts reduced, in which substantial CoV-specific Ab-producing plasma cells (sPC) were apoptotic. Apparent oxidative stress signs were observed in sPCs; the results were reproduced by exposing sPCs to CoV in the culture. The presence of MTL or/and HS prevented the CoV-induced oxidative stress in sPCs and promoted and stabilized the CoV Ab production in mice in re-exposure to CoV. In summary, CoV/Alum immunization can successfully induce CoV Ab production in mice that declines upon reexposure to CoV. Concurrent administration of MTL/HS stabilizes and promotes the CoV Ab production in mice.
  • |*Apoptosis[MESH]
  • |Adjuvants, Immunologic[MESH]
  • |Alcoholic Beverages[MESH]
  • |Alum Compounds[MESH]
  • |Angiotensin-Converting Enzyme 2/physiology[MESH]
  • |Animals[MESH]
  • |Antibodies, Neutralizing/*biosynthesis/blood[MESH]
  • |Antibodies, Viral/*biosynthesis/blood[MESH]
  • |COVID-19 Vaccines/immunology[MESH]
  • |COVID-19/enzymology/*immunology[MESH]
  • |Heat-Shock Response[MESH]
  • |Immunization, Secondary[MESH]
  • |Immunogenicity, Vaccine[MESH]
  • |Janus Kinase 2/physiology[MESH]
  • |Male[MESH]
  • |Mice[MESH]
  • |Mice, Inbred C57BL[MESH]
  • |Oxidative Stress[MESH]
  • |Plasma Cells/drug effects/*immunology/pathology[MESH]
  • |Reactive Oxygen Species/metabolism[MESH]
  • |SARS-CoV-2/*physiology[MESH]
  • |STAT1 Transcription Factor/physiology[MESH]
  • |Signal Transduction[MESH]
  • |Specific Pathogen-Free Organisms[MESH]
  • |Spike Glycoprotein, Coronavirus/immunology[MESH]
  • |Superoxide Dismutase-1/*physiology[MESH]


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