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10.1371/journal.pone.0262737

http://scihub22266oqcxt.onion/10.1371/journal.pone.0262737
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suck abstract from ncbi


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pmid35045126      PLoS+One 2022 ; 17 (1): e0262737
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  • Identification of hub genes associated with COVID-19 and idiopathic pulmonary fibrosis by integrated bioinformatics analysis #MMPMID35045126
  • Chen Q; Xia S; Sui H; Shi X; Huang B; Wang T
  • PLoS One 2022[]; 17 (1): e0262737 PMID35045126show ga
  • INTRODUCTION: The coronavirus disease 2019 (COVID-19), emerged in late 2019, was caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The risk factors for idiopathic pulmonary fibrosis (IPF) and COVID-19 are reported to be common. This study aimed to determine the potential role of differentially expressed genes (DEGs) common in IPF and COVID-19. MATERIALS AND METHODS: Based on GEO database, we obtained DEGs from one SARS-CoV-2 dataset and five IPF datasets. A series of enrichment analysis were performed to identify the function of upregulated and downregulated DEGs, respectively. Two plugins in Cytoscape, Cytohubba and MCODE, were utilized to identify hub genes after a protein-protein interaction (PPI) network. Finally, candidate drugs were predicted to target the upregulated DEGs. RESULTS: A total of 188 DEGs were found between COVID-19 and IPF, out of which 117 were upregulated and 71 were downregulated. The upregulated DEGs were involved in cytokine function, while downregulated DEGs were associated with extracellular matrix disassembly. Twenty-two hub genes were upregulated in COVID-19 and IPF, for which 155 candidate drugs were predicted (adj.P.value < 0.01). CONCLUSION: Identifying the hub genes aberrantly regulated in both COVID-19 and IPF may enable development of molecules, encoded by those genes, as therapeutic targets for preventing IPF progression and SARS-CoV-2 infections.
  • |COVID-19/*genetics/pathology/virology[MESH]
  • |Databases, Genetic[MESH]
  • |Down-Regulation/drug effects/genetics[MESH]
  • |Humans[MESH]
  • |Idiopathic Pulmonary Fibrosis/drug therapy/*genetics/pathology[MESH]
  • |Protein Interaction Maps/drug effects/genetics[MESH]
  • |SARS-CoV-2/isolation & purification[MESH]
  • |Suloctidil/pharmacology/therapeutic use[MESH]
  • |Up-Regulation/drug effects/genetics[MESH]


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