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10.21203/rs.3.rs-1225906/v1 http://scihub22266oqcxt.onion/10.21203/rs.3.rs-1225906/v1 35043109!8764723!35043109     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Res+Sq 2022 ; ä (ä): ä Nephropedia Template TP {{tp|p=35043109|t=2022. The risk of COVID-19 death is much greater and age-dependent with type I IFN autoantibodies |pdf=|usr=}}{{35043109}} gab.com Text The risk of COVID-19 death is much greater and age-dependent with type I IFN autoantibodies JO: Res Sq http://www.kidney.de/pget.php?&tw=1&pmid=35043109 #FOAvip SARS-CoV-2 infection fatality rate (IFR) doubles with every five years of age from childhood onward. Circulating autoantibodies neutralizing IFN-alpha, IFN-omega, and/or IFN-beta are found in ~20% of deceased patients across age groups. In the general population, they are found in ~1% of individuals aged 20-70 years and in >4% of those >70 years old. With a sample of 1,261 deceased patients and 34,159 uninfected individuals, we estimated both IFR and relative risk of death (RRD) across age groups for individuals carrying autoantibodies neutralizing type I IFNs, relative to non-carriers. For autoantibodies neutralizing IFN-alpha2 or IFN-omega, the RRD was 17.0[95% CI:11.7-24.7] for individuals under 70 years old and 5.8[4.5-7.4] for individuals aged 70 and over, whereas, for autoantibodies neutralizing both molecules, the RRD was 188.3[44.8-774.4] and 7.2[5.0-10.3], respectively. IFRs increased with age, from 0.17%[0.12-0.31] for individuals <40 years old to 26.7%[20.3-35.2] for those >/=80 years old for autoantibodies neutralizing IFN-alpha2 or IFN-omega, and from 0.84%[0.31-8.28] to 40.5%[27.82-61.20] for the same two age groups, for autoantibodies neutralizing both molecules. Autoantibodies against type I IFNs increase IFRs, and are associated with high RRDs, particularly those neutralizing both IFN-alpha2 and -omega. Remarkably, IFR increases with age, whereas RRD decreases with age. Autoimmunity to type I IFNs appears to be second only to age among common predictors of COVID-19 death. Twit Text FOAVip The risk of COVID-19 death is much greater and age-dependent with type I IFN autoantibodies ????Res Sq http://www.kidney.de/pget.php?&tw=1&pmid=35043109 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35043109 #FOAvip English Wikipedia <ref>{{Cite pmid|35043109}}</ref> The risk of COVID-19 death is much greater and age-dependent with type I IFN autoantibodies #MMPMID35043109 Manry J; Bastard P; Gervais A; Le Voyer T; Rosain J; Philippot Q; Michailidis E; Hoffmann HH; Eto S; Garcia-Prat M; Bizien L; Parra-Martinez A; Yang R; Haljasmagi L; Migaud M; Sarekannu K; Maslovskaja J; de Prost N; Tandjaoui-Lambiotte Y; Luyt CE; Amador-Borrero B; Gaudet A; Poissy J; Morel P; Richard P; Cognasse F; Troya J; Trouillet-Assant S; Belot A; Saker K; Garcon P; Riviere JG; Lagier JC; Gentile S; Rosen L; Shaw E; Morio T; Tanaka J; Dalmau D; Tharaux PL; Sene D; Stepanian A; Megarbane B; Triantafyllia V; Fekkar A; Heath J; Franco J; Anaya JM; Sole-Violan J; Imberti L; Biondi A; Bonfanti P; Castagnoli R; Delmonte O; Zhang Y; Snow A; Holland S; Biggs C; Moncada-Velez M; Arias A; Lorenzo L; Boucherit S; Anglicheau D; Planas A; Haerynck F; Duvlis S; Nussbaum R; Ozcelik T; Keles S; Bousfiha A; El Bakkouri J; Ramirez-Santana C; Paul S; Pan-Hammarstrom Q; Hammarstrom L; Dupont A; Kurolap A; Metz C; Aiuti A; Casari G; Lampasona V; Ciceri F; Barreiros L; Dominguez-Garrido E; Vidigal M; Zatz M; van de Beek D; Sahanic S; Tancevski I; Stepanovskyy Y; Boyarchuk O; Nukui Y; Tsumura M; Vidaur L; Tangye S; Burrel S; Duffy D; Quintana-Murci L; Klocperk A; Kann N; Shcherbina A; Lau YL; Leung D; Coulongeat M; Marlet J; Koning R; Reyes L; Chauvineau-Grenier A; Venet F; Monneret G; Nussenzweig M; Arrestier R; Boudhabhay I; Baris-Feldman H; Hagin D; Wauters J; Meyts I; Dyer A; Kennelly S; Bourke N; Halwani R; Sharif-Askari F; Dorgham K; Sallette J; Mehlal-Sedkaoui S; AlKhater S; Rigo-Bonnin R; Morandeira F; Roussel L; Vinh D; Erikstrup C; Condino-Neto A; Prando C; Bondarenko A; Spaan A; Gilardin L; Fellay J; Lyonnet S; Bilguvar K; Lifton R; Mane S; Anderson M; Boisson B; Beziat V; Zhang SY; Andreakos E; Hermine O; Pujol A; Peterson P; Mogensen TH; Rowen L; Mond J; Debette S; deLamballerie X; Burdet C; Bouadma L; Zins M; Soler-Palacin P; Colobran R; Gorochov G; Solanich X; Susen S; Martinez-Picado J; Raoult D; Vasse M; Gregersen P; Rodriguez-Gallego C; Piemonti L; Notarangelo L; Su H; Kisand K; Okada S; Puel A; Jouanguy E; Rice C; Tiberghien P; Zhang Q; Casanova JL; Abel L; Cobat A Res Sq 2022[Jan]; ä (ä): ä PMID35043109show ga SARS-CoV-2 infection fatality rate (IFR) doubles with every five years of age from childhood onward. Circulating autoantibodies neutralizing IFN-alpha, IFN-omega, and/or IFN-beta are found in ~20% of deceased patients across age groups. In the general population, they are found in ~1% of individuals aged 20-70 years and in >4% of those >70 years old. With a sample of 1,261 deceased patients and 34,159 uninfected individuals, we estimated both IFR and relative risk of death (RRD) across age groups for individuals carrying autoantibodies neutralizing type I IFNs, relative to non-carriers. For autoantibodies neutralizing IFN-alpha2 or IFN-omega, the RRD was 17.0[95% CI:11.7-24.7] for individuals under 70 years old and 5.8[4.5-7.4] for individuals aged 70 and over, whereas, for autoantibodies neutralizing both molecules, the RRD was 188.3[44.8-774.4] and 7.2[5.0-10.3], respectively. IFRs increased with age, from 0.17%[0.12-0.31] for individuals <40 years old to 26.7%[20.3-35.2] for those >/=80 years old for autoantibodies neutralizing IFN-alpha2 or IFN-omega, and from 0.84%[0.31-8.28] to 40.5%[27.82-61.20] for the same two age groups, for autoantibodies neutralizing both molecules. Autoantibodies against type I IFNs increase IFRs, and are associated with high RRDs, particularly those neutralizing both IFN-alpha2 and -omega. Remarkably, IFR increases with age, whereas RRD decreases with age. Autoimmunity to type I IFNs appears to be second only to age among common predictors of COVID-19 death. äThe risk of COVID-19 death is much greater and age-dependent with type(epmc).pdf DeepDyve Pubget Overpricing