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10.1038/s41591-022-01700-x http://scihub22266oqcxt.onion/10.1038/s41591-022-01700-x 35042228!8938268!35042228     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=35042228&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Med 2022 ; 28 (3): 472-476 Nephropedia Template TP {{tp|p=35042228|t=2022. Ancestral SARS-CoV-2-specific T cells cross-recognize the Omicron variant |pdf=|usr=}}{{35042228}} gab.com Text Ancestral SARS-CoV-2-specific T cells cross-recognize the Omicron variant JO: Nat Med http://www.kidney.de/pget.php?&tw=1&pmid=35042228 #FOAvip The emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron (B.1.1.529) variant of concern (VOC) has destabilized global efforts to control the impact of coronavirus disease 2019 (COVID-19). Recent data have suggested that B.1.1.529 can readily infect people with naturally acquired or vaccine-induced immunity, facilitated in some cases by viral escape from antibodies that neutralize ancestral SARS-CoV-2. However, severe disease appears to be relatively uncommon in such individuals, highlighting a potential role for other components of the adaptive immune system. We report here that SARS-CoV-2 spike-specific CD4(+) and CD8(+) T cells induced by prior infection or BNT162b2 vaccination provide extensive immune coverage against B.1.1.529. The median relative frequencies of SARS-CoV-2 spike-specific CD4(+) T cells that cross-recognized B.1.1.529 in previously infected or BNT162b2-vaccinated individuals were 84% and 91%, respectively, and the corresponding median relative frequencies for SARS-CoV-2 spike-specific CD8(+) T cells were 70% and 92%, respectively. Pairwise comparisons across groups further revealed that SARS-CoV-2 spike-reactive CD4(+) and CD8(+) T cells were functionally and phenotypically similar in response to the ancestral strain or B.1.1.529. Collectively, our data indicate that established SARS-CoV-2 spike-specific CD4(+) and CD8(+) T cell responses, especially after BNT162b2 vaccination, remain largely intact against B.1.1.529. Twit Text FOAVip Ancestral SARS-CoV-2-specific T cells cross-recognize the Omicron variant ????Nat Med http://www.kidney.de/pget.php?&tw=1&pmid=35042228 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35042228 #FOAvip English Wikipedia <ref>{{Cite pmid|35042228}}</ref> Ancestral SARS-CoV-2-specific T cells cross-recognize the Omicron variant #MMPMID35042228 Gao Y; Cai C; Grifoni A; Muller TR; Niessl J; Olofsson A; Humbert M; Hansson L; Osterborg A; Bergman P; Chen P; Olsson A; Sandberg JK; Weiskopf D; Price DA; Ljunggren HG; Karlsson AC; Sette A; Aleman S; Buggert M Nat Med 2022[Mar]; 28 (3): 472-476 PMID35042228show ga The emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron (B.1.1.529) variant of concern (VOC) has destabilized global efforts to control the impact of coronavirus disease 2019 (COVID-19). Recent data have suggested that B.1.1.529 can readily infect people with naturally acquired or vaccine-induced immunity, facilitated in some cases by viral escape from antibodies that neutralize ancestral SARS-CoV-2. However, severe disease appears to be relatively uncommon in such individuals, highlighting a potential role for other components of the adaptive immune system. We report here that SARS-CoV-2 spike-specific CD4(+) and CD8(+) T cells induced by prior infection or BNT162b2 vaccination provide extensive immune coverage against B.1.1.529. The median relative frequencies of SARS-CoV-2 spike-specific CD4(+) T cells that cross-recognized B.1.1.529 in previously infected or BNT162b2-vaccinated individuals were 84% and 91%, respectively, and the corresponding median relative frequencies for SARS-CoV-2 spike-specific CD8(+) T cells were 70% and 92%, respectively. Pairwise comparisons across groups further revealed that SARS-CoV-2 spike-reactive CD4(+) and CD8(+) T cells were functionally and phenotypically similar in response to the ancestral strain or B.1.1.529. Collectively, our data indicate that established SARS-CoV-2 spike-specific CD4(+) and CD8(+) T cell responses, especially after BNT162b2 vaccination, remain largely intact against B.1.1.529. |*COVID-19[MESH] |*Cross Protection[MESH] |*SARS-CoV-2[MESH] |Antibodies, Viral[MESH] |BNT162 Vaccine[MESH] |CD4-Positive T-Lymphocytes/*immunology[MESH] |CD8-Positive T-Lymphocytes/*immunology[MESH] |Humans[MESH]Ancestral SARS-CoV-2-specific T cells cross-recognize the Omicron vari(epmc).pdf DeepDyve Pubget Overpricing