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10.1016/j.jgg.2022.01.001 http://scihub22266oqcxt.onion/10.1016/j.jgg.2022.01.001 35032691!ä!35032691 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Genet+Genomics 2022 ; 49 (6): 523-536 Nephropedia Template TP {{tp|p=35032691|t=2022. Single-cell transcriptomic profiling of the hypothalamic median eminence during aging |pdf=|usr=}}{{35032691}} gab.com Text Single-cell transcriptomic profiling of the hypothalamic median eminence during aging JO: J Genet Genomics http://www.kidney.de/pget.php?&tw=1&pmid=35032691 #FOAvip Aging is a slow and progressive natural process that compromises the normal functions of cells, tissues, organs, and systems. The aging of the hypothalamic median eminence (ME), a structural gate linking neural and endocrine systems, may impair hormone release, energy homeostasis, and central sensing of circulating molecules, leading to systemic and reproductive aging. However, the molecular and cellular features of ME aging remain largely unknown. Here, we describe the transcriptional landscape of young and middle-aged mouse ME at single-cell resolution, revealing the common and cell type-specific transcriptional changes with age. The transcriptional changes in cell-intrinsic programs, cell-cell crosstalk, and cell-extrinsic factors highlight five molecular features of ME aging and also implicate several potentially druggable targets at cellular, signaling, and molecular levels. Importantly, our results suggest that vascular and leptomeningeal cells may lead the asynchronized aging process among diverse cell types and drive local inflammation and cellular senescence via a unique secretome. Together, our study uncovers how intrinsic and extrinsic features of each cell type in the hypothalamic ME are changed by the aging process, which will facilitate our understanding of brain aging and provide clues for efficient anti-aging intervention at the middle-aged stage. Twit Text FOAVip Single-cell transcriptomic profiling of the hypothalamic median eminence during aging ????J Genet Genomics http://www.kidney.de/pget.php?&tw=1&pmid=35032691 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35032691 #FOAvip English Wikipedia <ref>{{Cite pmid|35032691}}</ref> Single-cell transcriptomic profiling of the hypothalamic median eminence during aging #MMPMID35032691 Chen ZH; Li S; Xu M; Liu CC; Ye H; Wang B; Wu QF J Genet Genomics 2022[Jun]; 49 (6): 523-536 PMID35032691show ga Aging is a slow and progressive natural process that compromises the normal functions of cells, tissues, organs, and systems. The aging of the hypothalamic median eminence (ME), a structural gate linking neural and endocrine systems, may impair hormone release, energy homeostasis, and central sensing of circulating molecules, leading to systemic and reproductive aging. However, the molecular and cellular features of ME aging remain largely unknown. Here, we describe the transcriptional landscape of young and middle-aged mouse ME at single-cell resolution, revealing the common and cell type-specific transcriptional changes with age. The transcriptional changes in cell-intrinsic programs, cell-cell crosstalk, and cell-extrinsic factors highlight five molecular features of ME aging and also implicate several potentially druggable targets at cellular, signaling, and molecular levels. Importantly, our results suggest that vascular and leptomeningeal cells may lead the asynchronized aging process among diverse cell types and drive local inflammation and cellular senescence via a unique secretome. Together, our study uncovers how intrinsic and extrinsic features of each cell type in the hypothalamic ME are changed by the aging process, which will facilitate our understanding of brain aging and provide clues for efficient anti-aging intervention at the middle-aged stage. |*Median Eminence/metabolism[MESH] |*Transcriptome/genetics[MESH] |Aging/genetics/metabolism[MESH] |Animals[MESH] |Homeostasis[MESH] |Mice[MESH]Single-cell transcriptomic profiling of the hypothalamic median eminen(epmc).pdf DeepDyve Pubget Overpricing