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10.1016/j.stem.2021.12.010 http://scihub22266oqcxt.onion/10.1016/j.stem.2021.12.010 35032430!8709832!35032430     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Stem+Cell 2022 ; 29 (2): 217-231.e8 Nephropedia Template TP {{tp|p=35032430|t=2022. SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids |pdf=|usr=}}{{35032430}} gab.com Text SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids JO: Cell Stem Cell http://www.kidney.de/pget.php?&tw=1&pmid=35032430 #FOAvip Kidney failure is frequently observed during and after COVID-19, but it remains elusive whether this is a direct effect of the virus. Here, we report that SARS-CoV-2 directly infects kidney cells and is associated with increased tubule-interstitial kidney fibrosis in patient autopsy samples. To study direct effects of the virus on the kidney independent of systemic effects of COVID-19, we infected human-induced pluripotent stem-cell-derived kidney organoids with SARS-CoV-2. Single-cell RNA sequencing indicated injury and dedifferentiation of infected cells with activation of profibrotic signaling pathways. Importantly, SARS-CoV-2 infection also led to increased collagen 1 protein expression in organoids. A SARS-CoV-2 protease inhibitor was able to ameliorate the infection of kidney cells by SARS-CoV-2. Our results suggest that SARS-CoV-2 can directly infect kidney cells and induce cell injury with subsequent fibrosis. These data could explain both acute kidney injury in COVID-19 patients and the development of chronic kidney disease in long COVID. Twit Text FOAVip SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids ????Cell Stem Cell http://www.kidney.de/pget.php?&tw=1&pmid=35032430 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35032430 #FOAvip English Wikipedia <ref>{{Cite pmid|35032430}}</ref> SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids #MMPMID35032430 Jansen J; Reimer KC; Nagai JS; Varghese FS; Overheul GJ; de Beer M; Roverts R; Daviran D; Fermin LAS; Willemsen B; Beukenboom M; Djudjaj S; von Stillfried S; van Eijk LE; Mastik M; Bulthuis M; Dunnen WD; van Goor H; Hillebrands JL; Triana SH; Alexandrov T; Timm MC; van den Berge BT; van den Broek M; Nlandu Q; Heijnert J; Bindels EMJ; Hoogenboezem RM; Mooren F; Kuppe C; Miesen P; Grunberg K; Ijzermans T; Steenbergen EJ; Czogalla J; Schreuder MF; Sommerdijk N; Akiva A; Boor P; Puelles VG; Floege J; Huber TB; van Rij RP; Costa IG; Schneider RK; Smeets B; Kramann R Cell Stem Cell 2022[Feb]; 29 (2): 217-231.e8 PMID35032430show ga Kidney failure is frequently observed during and after COVID-19, but it remains elusive whether this is a direct effect of the virus. Here, we report that SARS-CoV-2 directly infects kidney cells and is associated with increased tubule-interstitial kidney fibrosis in patient autopsy samples. To study direct effects of the virus on the kidney independent of systemic effects of COVID-19, we infected human-induced pluripotent stem-cell-derived kidney organoids with SARS-CoV-2. Single-cell RNA sequencing indicated injury and dedifferentiation of infected cells with activation of profibrotic signaling pathways. Importantly, SARS-CoV-2 infection also led to increased collagen 1 protein expression in organoids. A SARS-CoV-2 protease inhibitor was able to ameliorate the infection of kidney cells by SARS-CoV-2. Our results suggest that SARS-CoV-2 can directly infect kidney cells and induce cell injury with subsequent fibrosis. These data could explain both acute kidney injury in COVID-19 patients and the development of chronic kidney disease in long COVID. |*COVID-19/complications[MESH] |*SARS-CoV-2[MESH] |Fibrosis[MESH] |Humans[MESH] |Kidney[MESH] |Organoids/pathology[MESH]SARS-CoV-2 infects the human kidney and drives fibrosis in kidney orga(epmc).pdf DeepDyve Pubget Overpricing