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10.1038/s41556-021-00821-8 http://scihub22266oqcxt.onion/10.1038/s41556-021-00821-8 35027731!8820466!35027731     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Cell+Biol 2022 ; 24 (1): 24-34 Nephropedia Template TP {{tp|p=35027731|t=2022. BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2 |pdf=|usr=}}{{35027731}} gab.com Text BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2 JO: Nat Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=35027731 #FOAvip SARS-CoV-2 infection of human cells is initiated by the binding of the viral Spike protein to its cell-surface receptor ACE2. We conducted a targeted CRISPRi screen to uncover druggable pathways controlling Spike protein binding to human cells. Here we show that the protein BRD2 is required for ACE2 transcription in human lung epithelial cells and cardiomyocytes, and BRD2 inhibitors currently evaluated in clinical trials potently block endogenous ACE2 expression and SARS-CoV-2 infection of human cells, including those of human nasal epithelia. Moreover, pharmacological BRD2 inhibition with the drug ABBV-744 inhibited SARS-CoV-2 replication in Syrian hamsters. We also found that BRD2 controls transcription of several other genes induced upon SARS-CoV-2 infection, including the interferon response, which in turn regulates the antiviral response. Together, our results pinpoint BRD2 as a potent and essential regulator of the host response to SARS-CoV-2 infection and highlight the potential of BRD2 as a therapeutic target for COVID-19. Twit Text FOAVip BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2 ????Nat Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=35027731 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35027731 #FOAvip English Wikipedia <ref>{{Cite pmid|35027731}}</ref> BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2 #MMPMID35027731 Samelson AJ; Tran QD; Robinot R; Carrau L; Rezelj VV; Kain AM; Chen M; Ramadoss GN; Guo X; Lim SA; Lui I; Nunez JK; Rockwood SJ; Wang J; Liu N; Carlson-Stevermer J; Oki J; Maures T; Holden K; Weissman JS; Wells JA; Conklin BR; TenOever BR; Chakrabarti LA; Vignuzzi M; Tian R; Kampmann M Nat Cell Biol 2022[Jan]; 24 (1): 24-34 PMID35027731show ga SARS-CoV-2 infection of human cells is initiated by the binding of the viral Spike protein to its cell-surface receptor ACE2. We conducted a targeted CRISPRi screen to uncover druggable pathways controlling Spike protein binding to human cells. Here we show that the protein BRD2 is required for ACE2 transcription in human lung epithelial cells and cardiomyocytes, and BRD2 inhibitors currently evaluated in clinical trials potently block endogenous ACE2 expression and SARS-CoV-2 infection of human cells, including those of human nasal epithelia. Moreover, pharmacological BRD2 inhibition with the drug ABBV-744 inhibited SARS-CoV-2 replication in Syrian hamsters. We also found that BRD2 controls transcription of several other genes induced upon SARS-CoV-2 infection, including the interferon response, which in turn regulates the antiviral response. Together, our results pinpoint BRD2 as a potent and essential regulator of the host response to SARS-CoV-2 infection and highlight the potential of BRD2 as a therapeutic target for COVID-19. |Angiotensin-Converting Enzyme 2/drug effects/*metabolism[MESH] |Antiviral Agents/*pharmacology[MESH] |COVID-19 Drug Treatment[MESH] |COVID-19/metabolism/virology[MESH] |Cell Line[MESH] |Epithelial Cells/metabolism/*virology[MESH] |Humans[MESH] |Membrane Glycoproteins/metabolism[MESH] |SARS-CoV-2/drug effects/*metabolism/pathogenicity[MESH]BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription (epmc).pdf DeepDyve Pubget Overpricing