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10.1016/j.celrep.2021.110271 http://scihub22266oqcxt.onion/10.1016/j.celrep.2021.110271 35026155!8712267!35026155     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=35026155&cmd=llinks): Failed to open stream: HTTP request failed! 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Proteomic and metabolomic profiling of urine uncovers immune responses in patients with COVID-19 |pdf=|usr=}}{{35026155}} gab.com Text Proteomic and metabolomic profiling of urine uncovers immune responses in patients with COVID-19 JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=35026155 #FOAvip The utility of the urinary proteome in infectious diseases remains unclear. Here, we analyzed the proteome and metabolome of urine and serum samples from patients with COVID-19 and healthy controls. Our data show that urinary proteins effectively classify COVID-19 by severity. We detect 197 cytokines and their receptors in urine, but only 124 in serum using TMT-based proteomics. The decrease in urinary ESCRT complex proteins correlates with active SARS-CoV-2 replication. The downregulation of urinary CXCL14 in severe COVID-19 cases positively correlates with blood lymphocyte counts. Integrative multiomics analysis suggests that innate immune activation and inflammation triggered renal injuries in patients with COVID-19. COVID-19-associated modulation of the urinary proteome offers unique insights into the pathogenesis of this disease. This study demonstrates the added value of including the urinary proteome in a suite of multiomics analytes in evaluating the immune pathobiology and clinical course of COVID-19 and, potentially, other infectious diseases. Twit Text FOAVip Proteomic and metabolomic profiling of urine uncovers immune responses in patients with COVID-19 ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=35026155 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35026155 #FOAvip English Wikipedia <ref>{{Cite pmid|35026155}}</ref> Proteomic and metabolomic profiling of urine uncovers immune responses in patients with COVID-19 #MMPMID35026155 Bi X; Liu W; Ding X; Liang S; Zheng Y; Zhu X; Quan S; Yi X; Xiang N; Du J; Lyu H; Yu D; Zhang C; Xu L; Ge W; Zhan X; He J; Xiong Z; Zhang S; Li Y; Xu P; Zhu G; Wang D; Zhu H; Chen S; Li J; Zhao H; Zhu Y; Liu H; Xu J; Shen B; Guo T Cell Rep 2022[Jan]; 38 (3): 110271 PMID35026155show ga The utility of the urinary proteome in infectious diseases remains unclear. Here, we analyzed the proteome and metabolome of urine and serum samples from patients with COVID-19 and healthy controls. Our data show that urinary proteins effectively classify COVID-19 by severity. We detect 197 cytokines and their receptors in urine, but only 124 in serum using TMT-based proteomics. The decrease in urinary ESCRT complex proteins correlates with active SARS-CoV-2 replication. The downregulation of urinary CXCL14 in severe COVID-19 cases positively correlates with blood lymphocyte counts. Integrative multiomics analysis suggests that innate immune activation and inflammation triggered renal injuries in patients with COVID-19. COVID-19-associated modulation of the urinary proteome offers unique insights into the pathogenesis of this disease. This study demonstrates the added value of including the urinary proteome in a suite of multiomics analytes in evaluating the immune pathobiology and clinical course of COVID-19 and, potentially, other infectious diseases. |*Immunity/physiology[MESH] |*Metabolome/immunology[MESH] |Adolescent[MESH] |Adult[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |COVID-19/blood/immunology/pathology/*urine[MESH] |Case-Control Studies[MESH] |Child[MESH] |Child, Preschool[MESH] |China[MESH] |Cohort Studies[MESH] |Female[MESH] |Humans[MESH] |Male[MESH] |Metabolomics[MESH] |Middle Aged[MESH] |Patient Acuity[MESH] |Proteome/*analysis/immunology/metabolism[MESH] |Proteomics[MESH] |SARS-CoV-2/*immunology[MESH] |Urinalysis/methods[MESH]Proteomic and metabolomic profiling of urine uncovers immune responses(epmc).pdf DeepDyve Pubget Overpricing