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10.1038/s42003-021-02983-5 http://scihub22266oqcxt.onion/10.1038/s42003-021-02983-5 35022513!8755718!35022513     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Commun+Biol 2022 ; 5 (1): 45 Nephropedia Template TP {{tp|p=35022513|t=2022. SARS-CoV-2 infection induces a pro-inflammatory cytokine response through cGAS-STING and NF-kappaB |pdf=|usr=}}{{35022513}} gab.com Text SARS-CoV-2 infection induces a pro-inflammatory cytokine response through cGAS-STING and NF-kappaB JO: Commun Biol http://www.kidney.de/pget.php?&tw=1&pmid=35022513 #FOAvip SARS-CoV-2 is a novel virus that has rapidly spread, causing a global pandemic. In the majority of infected patients, SARS-CoV-2 leads to mild disease; however, in a significant proportion of infections, individuals develop severe symptoms that can lead to long-lasting lung damage or death. These severe cases are often associated with high levels of pro-inflammatory cytokines and low antiviral responses, which can cause systemic complications. Here, we have evaluated transcriptional and cytokine secretion profiles and detected a distinct upregulation of inflammatory cytokines in infected cell cultures and samples taken from infected patients. Building on these observations, we found a specific activation of NF-kappaB and a block of IRF3 nuclear translocation in SARS-CoV-2 infected cells. This NF-kappaB response was mediated by cGAS-STING activation and could be attenuated through several STING-targeting drugs. Our results show that SARS-CoV-2 directs a cGAS-STING mediated, NF-kappaB-driven inflammatory immune response in human epithelial cells that likely contributes to inflammatory responses seen in patients and could be therapeutically targeted to suppress severe disease symptoms. Twit Text FOAVip SARS-CoV-2 infection induces a pro-inflammatory cytokine response through cGAS-STING and NF-kappaB ????Commun Biol http://www.kidney.de/pget.php?&tw=1&pmid=35022513 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35022513 #FOAvip English Wikipedia <ref>{{Cite pmid|35022513}}</ref> SARS-CoV-2 infection induces a pro-inflammatory cytokine response through cGAS-STING and NF-kappaB #MMPMID35022513 Neufeldt CJ; Cerikan B; Cortese M; Frankish J; Lee JY; Plociennikowska A; Heigwer F; Prasad V; Joecks S; Burkart SS; Zander DY; Subramanian B; Gimi R; Padmanabhan S; Iyer R; Gendarme M; El Debs B; Halama N; Merle U; Boutros M; Binder M; Bartenschlager R Commun Biol 2022[Jan]; 5 (1): 45 PMID35022513show ga SARS-CoV-2 is a novel virus that has rapidly spread, causing a global pandemic. In the majority of infected patients, SARS-CoV-2 leads to mild disease; however, in a significant proportion of infections, individuals develop severe symptoms that can lead to long-lasting lung damage or death. These severe cases are often associated with high levels of pro-inflammatory cytokines and low antiviral responses, which can cause systemic complications. Here, we have evaluated transcriptional and cytokine secretion profiles and detected a distinct upregulation of inflammatory cytokines in infected cell cultures and samples taken from infected patients. Building on these observations, we found a specific activation of NF-kappaB and a block of IRF3 nuclear translocation in SARS-CoV-2 infected cells. This NF-kappaB response was mediated by cGAS-STING activation and could be attenuated through several STING-targeting drugs. Our results show that SARS-CoV-2 directs a cGAS-STING mediated, NF-kappaB-driven inflammatory immune response in human epithelial cells that likely contributes to inflammatory responses seen in patients and could be therapeutically targeted to suppress severe disease symptoms. |*Cytokine Release Syndrome[MESH] |COVID-19/*metabolism/virology[MESH] |Humans[MESH] |Inflammation Mediators/*metabolism[MESH] |Membrane Proteins/*metabolism[MESH] |NF-kappa B/*metabolism[MESH] |Nucleotidyltransferases/*metabolism[MESH] |SARS-CoV-2/isolation & purification[MESH]SARS-CoV-2 infection induces a pro-inflammatory cytokine response thro(epmc).pdf DeepDyve Pubget Overpricing