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10.1038/s41467-021-27723-5 http://scihub22266oqcxt.onion/10.1038/s41467-021-27723-5 35022412!8755743!35022412     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=35022412&cmd=llinks): Failed to open stream: HTTP request failed! 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Postmortem high-dimensional immune profiling of severe COVID-19 patients reveals distinct patterns of immunosuppression and immunoactivation |pdf=|usr=}}{{35022412}} gab.com Text Postmortem high-dimensional immune profiling of severe COVID-19 patients reveals distinct patterns of immunosuppression and immunoactivation JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=35022412 #FOAvip A complete diagnostic autopsy is the gold-standard to gain insight into Coronavirus disease 2019 (COVID-19) pathogenesis. To delineate the in situ immune responses to SARS-CoV-2 viral infection, here we perform comprehensive high-dimensional transcriptional and spatial immune profiling in 22 COVID-19 decedents from Wuhan, China. We find TIM-3-mediated and PD-1-mediated immunosuppression as a hallmark of severe COVID-19, particularly in men, with PD-1(+) cells being proximal rather than distal to TIM-3(+) cells. Concurrently, lymphocytes are distal, while activated myeloid cells are proximal, to SARS-CoV-2 viral antigens, consistent with prevalent SARS-CoV-2 infection of myeloid cells in multiple organs. Finally, viral load positively correlates with specific immunosuppression and dendritic cell markers. In summary, our data show that SARS-CoV-2 viral infection induces lymphocyte suppression yet myeloid activation in severe COVID-19, so these two cell types likely have distinct functions in severe COVID-19 disease progression, and should be targeted differently for therapy. Twit Text FOAVip Postmortem high-dimensional immune profiling of severe COVID-19 patients reveals distinct patterns of immunosuppression and immunoactivation ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=35022412 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35022412 #FOAvip English Wikipedia <ref>{{Cite pmid|35022412}}</ref> Postmortem high-dimensional immune profiling of severe COVID-19 patients reveals distinct patterns of immunosuppression and immunoactivation #MMPMID35022412 Wu H; He P; Ren Y; Xiao S; Wang W; Liu Z; Li H; Wang Z; Zhang D; Cai J; Zhou X; Jiang D; Fei X; Zhao L; Zhang H; Liu Z; Chen R; Li W; Wang C; Zhang S; Qin J; Nashan B; Sun C Nat Commun 2022[Jan]; 13 (1): 269 PMID35022412show ga A complete diagnostic autopsy is the gold-standard to gain insight into Coronavirus disease 2019 (COVID-19) pathogenesis. To delineate the in situ immune responses to SARS-CoV-2 viral infection, here we perform comprehensive high-dimensional transcriptional and spatial immune profiling in 22 COVID-19 decedents from Wuhan, China. We find TIM-3-mediated and PD-1-mediated immunosuppression as a hallmark of severe COVID-19, particularly in men, with PD-1(+) cells being proximal rather than distal to TIM-3(+) cells. Concurrently, lymphocytes are distal, while activated myeloid cells are proximal, to SARS-CoV-2 viral antigens, consistent with prevalent SARS-CoV-2 infection of myeloid cells in multiple organs. Finally, viral load positively correlates with specific immunosuppression and dendritic cell markers. In summary, our data show that SARS-CoV-2 viral infection induces lymphocyte suppression yet myeloid activation in severe COVID-19, so these two cell types likely have distinct functions in severe COVID-19 disease progression, and should be targeted differently for therapy. |Aged[MESH] |Autopsy[MESH] |COVID-19/diagnosis/genetics/*immunology/virology[MESH] |China[MESH] |Diagnosis[MESH] |Female[MESH] |Hepatitis A Virus Cellular Receptor 2/genetics/immunology[MESH] |Humans[MESH] |Immunosuppression Therapy[MESH] |Lymphocyte Activation[MESH] |Lymphocytes/immunology[MESH] |Male[MESH] |Middle Aged[MESH] |Myeloid Cells/immunology[MESH] |Programmed Cell Death 1 Receptor/genetics/immunology[MESH] |SARS-CoV-2/immunology/*physiology[MESH]Postmortem high-dimensional immune profiling of severe COVID-19 patien(epmc).pdf DeepDyve Pubget Overpricing