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10.1073/pnas.2117576119 http://scihub22266oqcxt.onion/10.1073/pnas.2117576119 35022217!8794821!35022217     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2022 ; 119 (4): ä Nephropedia Template TP {{tp|p=35022217|t=2022. SNX27 suppresses SARS-CoV-2 infection by inhibiting viral lysosome/late endosome entry |pdf=|usr=}}{{35022217}} gab.com Text SNX27 suppresses SARS-CoV-2 infection by inhibiting viral lysosome/late endosome entry JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=35022217 #FOAvip After binding to its cell surface receptor angiotensin converting enzyme 2 (ACE2), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enters the host cell through directly fusing with plasma membrane (cell surface pathway) or undergoing endocytosis traveling to lysosome/late endosome for membrane fusion (endocytic pathway). However, the endocytic entry regulation by host cell remains elusive. Recent studies show ACE2 possesses a type I PDZ binding motif (PBM) through which it could interact with a PDZ domain-containing protein such as sorting nexin 27 (SNX27). In this study, we determined the ACE2-PBM/SNX27-PDZ complex structure, and, through a series of functional analyses, we found SNX27 plays an important role in regulating the homeostasis of ACE2 receptor. More importantly, we demonstrated SNX27, together with retromer complex (the core component of the endosomal protein sorting machinery), prevents ACE2/virus complex from entering lysosome/late endosome, resulting in decreased viral entry in cells where the endocytic pathway dominates. The ACE2/virus retrieval mediated by SNX27-retromer could be considered as a countermeasure against invasion of ACE2 receptor-using SARS coronaviruses. Twit Text FOAVip SNX27 suppresses SARS-CoV-2 infection by inhibiting viral lysosome/late endosome entry ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=35022217 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35022217 #FOAvip English Wikipedia <ref>{{Cite pmid|35022217}}</ref> SNX27 suppresses SARS-CoV-2 infection by inhibiting viral lysosome/late endosome entry #MMPMID35022217 Yang B; Jia Y; Meng Y; Xue Y; Liu K; Li Y; Liu S; Li X; Cui K; Shang L; Cheng T; Zhang Z; Hou Y; Yang X; Yan H; Duan L; Tong Z; Wu C; Liu Z; Gao S; Zhuo S; Huang W; Gao GF; Qi J; Shang G Proc Natl Acad Sci U S A 2022[Jan]; 119 (4): ä PMID35022217show ga After binding to its cell surface receptor angiotensin converting enzyme 2 (ACE2), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enters the host cell through directly fusing with plasma membrane (cell surface pathway) or undergoing endocytosis traveling to lysosome/late endosome for membrane fusion (endocytic pathway). However, the endocytic entry regulation by host cell remains elusive. Recent studies show ACE2 possesses a type I PDZ binding motif (PBM) through which it could interact with a PDZ domain-containing protein such as sorting nexin 27 (SNX27). In this study, we determined the ACE2-PBM/SNX27-PDZ complex structure, and, through a series of functional analyses, we found SNX27 plays an important role in regulating the homeostasis of ACE2 receptor. More importantly, we demonstrated SNX27, together with retromer complex (the core component of the endosomal protein sorting machinery), prevents ACE2/virus complex from entering lysosome/late endosome, resulting in decreased viral entry in cells where the endocytic pathway dominates. The ACE2/virus retrieval mediated by SNX27-retromer could be considered as a countermeasure against invasion of ACE2 receptor-using SARS coronaviruses. |*SARS-CoV-2[MESH] |Angiotensin-Converting Enzyme 2/*metabolism[MESH] |COVID-19/*metabolism/virology[MESH] |Cell Line[MESH] |Cell Line, Tumor[MESH] |Cell Membrane/metabolism[MESH] |Crystallography, X-Ray[MESH] |Cytosol/metabolism[MESH] |Endocytosis[MESH] |Endosomes/*metabolism[MESH] |Gene Expression Profiling[MESH] |HEK293 Cells[MESH] |HeLa Cells[MESH] |Homeostasis[MESH] |Humans[MESH] |Lentivirus[MESH] |Lysosomes/metabolism[MESH] |Peptides/chemistry[MESH] |Protein Binding[MESH] |Protein Conformation[MESH] |Protein Domains[MESH] |Sorting Nexins/*chemistry/metabolism[MESH]SNX27 suppresses SARS-CoV-2 infection by inhibiting viral lysosome/lat(epmc).pdf DeepDyve Pubget Overpricing