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10.1038/s41467-021-27881-6 http://scihub22266oqcxt.onion/10.1038/s41467-021-27881-6 35017512!8752678!35017512     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2022 ; 13 (1): 222 Nephropedia Template TP {{tp|p=35017512|t=2022. Structural insights in cell-type specific evolution of intra-host diversity by SARS-CoV-2 |pdf=|usr=}}{{35017512}} gab.com Text Structural insights in cell-type specific evolution of intra-host diversity by SARS-CoV-2 JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=35017512 #FOAvip As the global burden of SARS-CoV-2 infections escalates, so does the evolution of viral variants with increased transmissibility and pathology. In addition to this entrenched diversity, RNA viruses can also display genetic diversity within single infected hosts with co-existing viral variants evolving differently in distinct cell types. The BriSDelta variant, originally identified as a viral subpopulation from SARS-CoV-2 isolate hCoV-19/England/02/2020, comprises in the spike an eight amino-acid deletion encompassing a furin recognition motif and S1/S2 cleavage site. We elucidate the structure, function and molecular dynamics of this spike providing mechanistic insight into how the deletion correlates to viral cell tropism, ACE2 receptor binding and infectivity of this SARS-CoV-2 variant. Our results reveal long-range allosteric communication between functional domains that differ in the wild-type and the deletion variant and support a view of SARS-CoV-2 probing multiple evolutionary trajectories in distinct cell types within the same infected host. Twit Text FOAVip Structural insights in cell-type specific evolution of intra-host diversity by SARS-CoV-2 ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=35017512 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35017512 #FOAvip English Wikipedia <ref>{{Cite pmid|35017512}}</ref> Structural insights in cell-type specific evolution of intra-host diversity by SARS-CoV-2 #MMPMID35017512 Gupta K; Toelzer C; Williamson MK; Shoemark DK; Oliveira ASF; Matthews DA; Almuqrin A; Staufer O; Yadav SKN; Borucu U; Garzoni F; Fitzgerald D; Spatz J; Mulholland AJ; Davidson AD; Schaffitzel C; Berger I Nat Commun 2022[Jan]; 13 (1): 222 PMID35017512show ga As the global burden of SARS-CoV-2 infections escalates, so does the evolution of viral variants with increased transmissibility and pathology. In addition to this entrenched diversity, RNA viruses can also display genetic diversity within single infected hosts with co-existing viral variants evolving differently in distinct cell types. The BriSDelta variant, originally identified as a viral subpopulation from SARS-CoV-2 isolate hCoV-19/England/02/2020, comprises in the spike an eight amino-acid deletion encompassing a furin recognition motif and S1/S2 cleavage site. We elucidate the structure, function and molecular dynamics of this spike providing mechanistic insight into how the deletion correlates to viral cell tropism, ACE2 receptor binding and infectivity of this SARS-CoV-2 variant. Our results reveal long-range allosteric communication between functional domains that differ in the wild-type and the deletion variant and support a view of SARS-CoV-2 probing multiple evolutionary trajectories in distinct cell types within the same infected host. |Animals[MESH] |COVID-19/virology[MESH] |Cell Line[MESH] |Cryoelectron Microscopy[MESH] |Evolution, Molecular[MESH] |Furin/metabolism[MESH] |Humans[MESH] |Linoleic Acid/metabolism[MESH] |Molecular Dynamics Simulation[MESH] |Mutation[MESH] |Protein Binding[MESH] |Protein Conformation[MESH] |SARS-CoV-2/*chemistry/*genetics/physiology[MESH] |Spike Glycoprotein, Coronavirus/chemistry/genetics/metabolism[MESH] |Viral Tropism[MESH]Structural insights in cell-type specific evolution of intra-host dive(epmc).pdf DeepDyve Pubget Overpricing