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10.1038/s10038-021-01009-6 http://scihub22266oqcxt.onion/10.1038/s10038-021-01009-6 35013560!8748005!35013560     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Hum+Genet 2022 ; 67 (5): 295-301 Nephropedia Template TP {{tp|p=35013560|t=2022. Host genetic factors of COVID-19 susceptibility and disease severity in a Thai population |pdf=|usr=}}{{35013560}} gab.com Text Host genetic factors of COVID-19 susceptibility and disease severity in a Thai population JO: J Hum Genet http://www.kidney.de/pget.php?&tw=1&pmid=35013560 #FOAvip Host genetic factors have been shown to play a role in SARs-CoV-2 infection in diverse populations. However, the genetic landscape differs among various ethnicities; therefore, we explored the host genetic factors associated with COVID-19 disease susceptivity and disease severity in a Thai population. We recruited and genotyped 212 unrelated COVID-19 Thai patients and 36 controls using Axiom(TM) Human Genotyping SARs-COV-2 array, including 847,384 single nucleotide polymorphisms related to SARs-COV-2 pathogenesis, immune response, and related comorbidity No SNPs passed the genome-wide significance threshold of p value <1 x 10(-8). However, with a threshold of p value <1 x 10(-5), a locus on chromosome 5q32 was found to have a suggestive association with COVID-19 disease susceptibility (p value 6.9 x 10(-6); Q-Q plot lambda = 0.805, odds ratio 0.02). Notably, IL17B is a gene located in this linkage disequilibrium block and is previously shown to play a part in inflammation and pneumonia. Additionally, a suggestive locus on chromosome 12q22, harboring EEA1 and LOC643339, was associated with COVID-19 disease severity (p value 1.3 x 10(-6) - 4.4 x 10(-6), Q-Q plot lambda = 0.997, odds ratio 0.28-0.31). EEA1 is involved in viral entry into cells, while LOC643339 is a long non-coding RNA. In summary, our study suggested loci on chromosomes 5q32 and 12q22 to be linked to COVID-19 disease susceptibility and disease severity, respectively. The small sample size of this study may lessen the likelihood that the association found is real, but it could still be true. Further study with a larger cohort is required to confirm these findings. Twit Text FOAVip Host genetic factors of COVID-19 susceptibility and disease severity in a Thai population ????J Hum Genet http://www.kidney.de/pget.php?&tw=1&pmid=35013560 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35013560 #FOAvip English Wikipedia <ref>{{Cite pmid|35013560}}</ref> Host genetic factors of COVID-19 susceptibility and disease severity in a Thai population #MMPMID35013560 Chamnanphon M; Pongpanich M; Suttichet TB; Jantarabenjakul W; Torvorapanit P; Putcharoen O; Sodsai P; Phokaew C; Hirankarn N; Chariyavilaskul P; Shotelersuk V J Hum Genet 2022[May]; 67 (5): 295-301 PMID35013560show ga Host genetic factors have been shown to play a role in SARs-CoV-2 infection in diverse populations. However, the genetic landscape differs among various ethnicities; therefore, we explored the host genetic factors associated with COVID-19 disease susceptivity and disease severity in a Thai population. We recruited and genotyped 212 unrelated COVID-19 Thai patients and 36 controls using Axiom(TM) Human Genotyping SARs-COV-2 array, including 847,384 single nucleotide polymorphisms related to SARs-COV-2 pathogenesis, immune response, and related comorbidity No SNPs passed the genome-wide significance threshold of p value <1 x 10(-8). However, with a threshold of p value <1 x 10(-5), a locus on chromosome 5q32 was found to have a suggestive association with COVID-19 disease susceptibility (p value 6.9 x 10(-6); Q-Q plot lambda = 0.805, odds ratio 0.02). Notably, IL17B is a gene located in this linkage disequilibrium block and is previously shown to play a part in inflammation and pneumonia. Additionally, a suggestive locus on chromosome 12q22, harboring EEA1 and LOC643339, was associated with COVID-19 disease severity (p value 1.3 x 10(-6) - 4.4 x 10(-6), Q-Q plot lambda = 0.997, odds ratio 0.28-0.31). EEA1 is involved in viral entry into cells, while LOC643339 is a long non-coding RNA. In summary, our study suggested loci on chromosomes 5q32 and 12q22 to be linked to COVID-19 disease susceptibility and disease severity, respectively. The small sample size of this study may lessen the likelihood that the association found is real, but it could still be true. Further study with a larger cohort is required to confirm these findings. |*COVID-19/epidemiology/genetics[MESH] |Genetic Predisposition to Disease[MESH] |Genome-Wide Association Study[MESH] |Humans[MESH] |Polymorphism, Single Nucleotide[MESH] |SARS-CoV-2[MESH] |Severity of Illness Index[MESH]Host genetic factors of COVID-19 susceptibility and disease severity i(epmc).pdf DeepDyve Pubget Overpricing