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10.1038/s41467-021-27674-x http://scihub22266oqcxt.onion/10.1038/s41467-021-27674-x 35013199!8748880!35013199     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2022 ; 13 (1): 80 Nephropedia Template TP {{tp|p=35013199|t=2022. Cross-reactive memory T cells associate with protection against SARS-CoV-2 infection in COVID-19 contacts |pdf=|usr=}}{{35013199}} gab.com Text Cross-reactive memory T cells associate with protection against SARS-CoV-2 infection in COVID-19 contacts JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=35013199 #FOAvip Cross-reactive immune responses to SARS-CoV-2 have been observed in pre-pandemic cohorts and proposed to contribute to host protection. Here we assess 52 COVID-19 household contacts to capture immune responses at the earliest timepoints after SARS-CoV-2 exposure. Using a dual cytokine FLISpot assay on peripheral blood mononuclear cells, we enumerate the frequency of T cells specific for spike, nucleocapsid, membrane, envelope and ORF1 SARS-CoV-2 epitopes that cross-react with human endemic coronaviruses. We observe higher frequencies of cross-reactive (p = 0.0139), and nucleocapsid-specific (p = 0.0355) IL-2-secreting memory T cells in contacts who remained PCR-negative despite exposure (n = 26), when compared with those who convert to PCR-positive (n = 26); no significant difference in the frequency of responses to spike is observed, hinting at a limited protective function of spike-cross-reactive T cells. Our results are thus consistent with pre-existing non-spike cross-reactive memory T cells protecting SARS-CoV-2-naive contacts from infection, thereby supporting the inclusion of non-spike antigens in second-generation vaccines. Twit Text FOAVip Cross-reactive memory T cells associate with protection against SARS-CoV-2 infection in COVID-19 contacts ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=35013199 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35013199 #FOAvip English Wikipedia <ref>{{Cite pmid|35013199}}</ref> Cross-reactive memory T cells associate with protection against SARS-CoV-2 infection in COVID-19 contacts #MMPMID35013199 Kundu R; Narean JS; Wang L; Fenn J; Pillay T; Fernandez ND; Conibear E; Koycheva A; Davies M; Tolosa-Wright M; Hakki S; Varro R; McDermott E; Hammett S; Cutajar J; Thwaites RS; Parker E; Rosadas C; McClure M; Tedder R; Taylor GP; Dunning J; Lalvani A Nat Commun 2022[Jan]; 13 (1): 80 PMID35013199show ga Cross-reactive immune responses to SARS-CoV-2 have been observed in pre-pandemic cohorts and proposed to contribute to host protection. Here we assess 52 COVID-19 household contacts to capture immune responses at the earliest timepoints after SARS-CoV-2 exposure. Using a dual cytokine FLISpot assay on peripheral blood mononuclear cells, we enumerate the frequency of T cells specific for spike, nucleocapsid, membrane, envelope and ORF1 SARS-CoV-2 epitopes that cross-react with human endemic coronaviruses. We observe higher frequencies of cross-reactive (p = 0.0139), and nucleocapsid-specific (p = 0.0355) IL-2-secreting memory T cells in contacts who remained PCR-negative despite exposure (n = 26), when compared with those who convert to PCR-positive (n = 26); no significant difference in the frequency of responses to spike is observed, hinting at a limited protective function of spike-cross-reactive T cells. Our results are thus consistent with pre-existing non-spike cross-reactive memory T cells protecting SARS-CoV-2-naive contacts from infection, thereby supporting the inclusion of non-spike antigens in second-generation vaccines. |Adult[MESH] |Antibodies, Viral/*immunology[MESH] |COVID-19/epidemiology/*immunology/virology[MESH] |Contact Tracing/*methods[MESH] |Coronavirus/immunology/physiology[MESH] |Cross Reactions/*immunology[MESH] |Epitopes, T-Lymphocyte/immunology[MESH] |Female[MESH] |Humans[MESH] |Male[MESH] |Memory T Cells/*immunology/metabolism/virology[MESH] |Middle Aged[MESH] |Pandemics/prevention & control[MESH] |SARS-CoV-2/genetics/*immunology/physiology[MESH] |Spike Glycoprotein, Coronavirus/genetics/immunology/metabolism[MESH] |Viral Proteins/genetics/immunology/metabolism[MESH]Cross-reactive memory T cells associate with protection against SARS-C(epmc).pdf DeepDyve Pubget Overpricing