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Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Nat+Commun 2022 ; 13 (1): 80 Nephropedia Template TP
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Cross-reactive memory T cells associate with protection against SARS-CoV-2 infection in COVID-19 contacts #MMPMID35013199
Kundu R; Narean JS; Wang L; Fenn J; Pillay T; Fernandez ND; Conibear E; Koycheva A; Davies M; Tolosa-Wright M; Hakki S; Varro R; McDermott E; Hammett S; Cutajar J; Thwaites RS; Parker E; Rosadas C; McClure M; Tedder R; Taylor GP; Dunning J; Lalvani A
Nat Commun 2022[Jan]; 13 (1): 80 PMID35013199show ga
Cross-reactive immune responses to SARS-CoV-2 have been observed in pre-pandemic cohorts and proposed to contribute to host protection. Here we assess 52 COVID-19 household contacts to capture immune responses at the earliest timepoints after SARS-CoV-2 exposure. Using a dual cytokine FLISpot assay on peripheral blood mononuclear cells, we enumerate the frequency of T cells specific for spike, nucleocapsid, membrane, envelope and ORF1 SARS-CoV-2 epitopes that cross-react with human endemic coronaviruses. We observe higher frequencies of cross-reactive (p = 0.0139), and nucleocapsid-specific (p = 0.0355) IL-2-secreting memory T cells in contacts who remained PCR-negative despite exposure (n = 26), when compared with those who convert to PCR-positive (n = 26); no significant difference in the frequency of responses to spike is observed, hinting at a limited protective function of spike-cross-reactive T cells. Our results are thus consistent with pre-existing non-spike cross-reactive memory T cells protecting SARS-CoV-2-naive contacts from infection, thereby supporting the inclusion of non-spike antigens in second-generation vaccines.
|Adult[MESH]
|Antibodies, Viral/*immunology[MESH]
|COVID-19/epidemiology/*immunology/virology[MESH]
|Contact Tracing/*methods[MESH]
|Coronavirus/immunology/physiology[MESH]
|Cross Reactions/*immunology[MESH]
|Epitopes, T-Lymphocyte/immunology[MESH]
|Female[MESH]
|Humans[MESH]
|Male[MESH]
|Memory T Cells/*immunology/metabolism/virology[MESH]