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10.3390/cells11010045 http://scihub22266oqcxt.onion/10.3390/cells11010045 35011607!8750383!35011607     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cells 2021 ; 11 (1): ä Nephropedia Template TP {{tp|p=35011607|t=2021. Channels and Transporters of the Pulmonary Lamellar Body in Health and Disease |pdf=|usr=}}{{35011607}} gab.com Text Channels and Transporters of the Pulmonary Lamellar Body in Health and Disease JO: Cells http://www.kidney.de/pget.php?&tw=1&pmid=35011607 #FOAvip The lamellar body (LB) of the alveolar type II (ATII) cell is a lysosome-related organelle (LRO) that contains surfactant, a complex mix of mainly lipids and specific surfactant proteins. The major function of surfactant in the lung is the reduction of surface tension and stabilization of alveoli during respiration. Its lack or deficiency may cause various forms of respiratory distress syndrome (RDS). Surfactant is also part of the innate immune system in the lung, defending the organism against air-borne pathogens. The limiting (organelle) membrane that encloses the LB contains various transporters that are in part responsible for translocating lipids and other organic material into the LB. On the other hand, this membrane contains ion transporters and channels that maintain a specific internal ion composition including the acidic pH of about 5. Furthermore, P2X(4) receptors, ligand gated ion channels of the danger signal ATP, are expressed in the limiting LB membrane. They play a role in boosting surfactant secretion and fluid clearance. In this review, we discuss the functions of these transporting pathways of the LB, including possible roles in disease and as therapeutic targets, including viral infections such as SARS-CoV-2. Twit Text FOAVip Channels and Transporters of the Pulmonary Lamellar Body in Health and Disease ????Cells http://www.kidney.de/pget.php?&tw=1&pmid=35011607 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35011607 #FOAvip English Wikipedia <ref>{{Cite pmid|35011607}}</ref> Channels and Transporters of the Pulmonary Lamellar Body in Health and Disease #MMPMID35011607 Dietl P; Frick M Cells 2021[Dec]; 11 (1): ä PMID35011607show ga The lamellar body (LB) of the alveolar type II (ATII) cell is a lysosome-related organelle (LRO) that contains surfactant, a complex mix of mainly lipids and specific surfactant proteins. The major function of surfactant in the lung is the reduction of surface tension and stabilization of alveoli during respiration. Its lack or deficiency may cause various forms of respiratory distress syndrome (RDS). Surfactant is also part of the innate immune system in the lung, defending the organism against air-borne pathogens. The limiting (organelle) membrane that encloses the LB contains various transporters that are in part responsible for translocating lipids and other organic material into the LB. On the other hand, this membrane contains ion transporters and channels that maintain a specific internal ion composition including the acidic pH of about 5. Furthermore, P2X(4) receptors, ligand gated ion channels of the danger signal ATP, are expressed in the limiting LB membrane. They play a role in boosting surfactant secretion and fluid clearance. In this review, we discuss the functions of these transporting pathways of the LB, including possible roles in disease and as therapeutic targets, including viral infections such as SARS-CoV-2. |COVID-19/*metabolism/virology[MESH] |Humans[MESH] |Ion Channels/*metabolism[MESH] |Lamellar Bodies/*metabolism[MESH] |Lung/*metabolism/virology[MESH] |Membrane Transport Proteins/*metabolism[MESH] |Organelles/metabolism/virology[MESH] |Pulmonary Alveoli/metabolism/virology[MESH] |Pulmonary Surfactants/*metabolism[MESH]Channels and Transporters of the Pulmonary Lamellar Body in Health and(epmc).pdf DeepDyve Pubget Overpricing