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10.1016/j.isci.2021.103720 http://scihub22266oqcxt.onion/10.1016/j.isci.2021.103720 35005526!8719361!35005526     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       iScience 2022 ; 25 (1): 103720 Nephropedia Template TP {{tp|p=35005526|t=2022. ACE2 can act as the secondary receptor in the FcgammaR-dependent ADE of SARS-CoV-2 infection |pdf=|usr=}}{{35005526}} gab.com Text ACE2 can act as the secondary receptor in the FcgammaR-dependent ADE of SARS-CoV-2 infection JO: iScience http://www.kidney.de/pget.php?&tw=1&pmid=35005526 #FOAvip It is unknown whether antibody-mediated enhancement (ADE) contributes to the pathogenesis of COVID-19, and the conditions for ADE needs to be elucidated. We demonstrated that without inducing an ACE2-independent ADE on Raji cells, the neutralizing antibody CB6, a mouse anti-S1 serum and convalescent plasma, induced ADE on cells expressing FcgammaRIIA/CD32A and low levels of endogenous ACE2. ADE occurred at sub-neutralizing antibody concentrations, indicating that unneutralized S protein was required for ADE. The enhanced infectivity of 614G variant was higher than that of 614D wildtype in the presence of antibodies, further suggesting that ADE may be influenced by virus strains with different ACE2-binding affinity. Finally, knockdown of ACE2 or treatment with a fusion-inhibition peptide EK1C4 significantly reduced ADE. In conclusion, we identified an ADE mechanism mediated by neutralizing antibodies against SARS-CoV-2. ACE2 may act as a secondary receptor required for the antibody- and FcgammaR-mediated enhanced entry of SARS-CoV-2. Twit Text FOAVip ACE2 can act as the secondary receptor in the FcgammaR-dependent ADE of SARS-CoV-2 infection ????iScience http://www.kidney.de/pget.php?&tw=1&pmid=35005526 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35005526 #FOAvip English Wikipedia <ref>{{Cite pmid|35005526}}</ref> ACE2 can act as the secondary receptor in the FcgammaR-dependent ADE of SARS-CoV-2 infection #MMPMID35005526 Wang Z; Deng T; Zhang Y; Niu W; Nie Q; Yang S; Liu P; Pei P; Chen L; Li H; Cao B iScience 2022[Jan]; 25 (1): 103720 PMID35005526show ga It is unknown whether antibody-mediated enhancement (ADE) contributes to the pathogenesis of COVID-19, and the conditions for ADE needs to be elucidated. We demonstrated that without inducing an ACE2-independent ADE on Raji cells, the neutralizing antibody CB6, a mouse anti-S1 serum and convalescent plasma, induced ADE on cells expressing FcgammaRIIA/CD32A and low levels of endogenous ACE2. ADE occurred at sub-neutralizing antibody concentrations, indicating that unneutralized S protein was required for ADE. The enhanced infectivity of 614G variant was higher than that of 614D wildtype in the presence of antibodies, further suggesting that ADE may be influenced by virus strains with different ACE2-binding affinity. Finally, knockdown of ACE2 or treatment with a fusion-inhibition peptide EK1C4 significantly reduced ADE. In conclusion, we identified an ADE mechanism mediated by neutralizing antibodies against SARS-CoV-2. ACE2 may act as a secondary receptor required for the antibody- and FcgammaR-mediated enhanced entry of SARS-CoV-2. äACE2 can act as the secondary receptor in the FcgammaR-dependent ADE o(epmc).pdf DeepDyve Pubget Overpricing