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10.3389/fphys.2021.771960 http://scihub22266oqcxt.onion/10.3389/fphys.2021.771960 35002759!8733629!35002759     free     free     free       Front+Physiol 2021 ; 12 (?): 771960 Nephropedia Template TP {{tp|p=35002759|t=2021. Mechanobiology of Microvascular Function and Structure in Health and Disease: Focus on the Coronary Circulation |pdf=|usr=}}{{35002759}} gab.com Text Mechanobiology of Microvascular Function and Structure in Health and Disease: Focus on the Coronary Circulation JO: Front Physiol http://www.kidney.de/pget.php?&tw=1&pmid=35002759 #FOAvip The coronary microvasculature plays a key role in regulating the tight coupling between myocardial perfusion and myocardial oxygen demand across a wide range of cardiac activity. Short-term regulation of coronary blood flow in response to metabolic stimuli is achieved via adjustment of vascular diameter in different segments of the microvasculature in conjunction with mechanical forces eliciting myogenic and flow-mediated vasodilation. In contrast, chronic adjustments in flow regulation also involve microvascular structural modifications, termed remodeling. Vascular remodeling encompasses changes in microvascular diameter and/or density being largely modulated by mechanical forces acting on the endothelium and vascular smooth muscle cells. Whereas in recent years, substantial knowledge has been gathered regarding the molecular mechanisms controlling microvascular tone and how these are altered in various diseases, the structural adaptations in response to pathologic situations are less well understood. In this article, we review the factors involved in coronary microvascular functional and structural alterations in obstructive and non-obstructive coronary artery disease and the molecular mechanisms involved therein with a focus on mechanobiology. Cardiovascular risk factors including metabolic dysregulation, hypercholesterolemia, hypertension and aging have been shown to induce microvascular (endothelial) dysfunction and vascular remodeling. Additionally, alterations in biomechanical forces produced by a coronary artery stenosis are associated with microvascular functional and structural alterations. Future studies should be directed at further unraveling the mechanisms underlying the coronary microvascular functional and structural alterations in disease; a deeper understanding of these mechanisms is critical for the identification of potential new targets for the treatment of ischemic heart disease. Twit Text FOAVip Mechanobiology of Microvascular Function and Structure in Health and Disease: Focus on the Coronary Circulation ????Front Physiol http://www.kidney.de/pget.php?&tw=1&pmid=35002759 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35002759 #FOAvip English Wikipedia <ref>{{Cite pmid|35002759}}</ref> Mechanobiology of Microvascular Function and Structure in Health and Disease: Focus on the Coronary Circulation #MMPMID35002759 Brandt MM; Cheng C; Merkus D; Duncker DJ; Sorop O Front Physiol 2021[]; 12 (?): 771960 PMID35002759show ga The coronary microvasculature plays a key role in regulating the tight coupling between myocardial perfusion and myocardial oxygen demand across a wide range of cardiac activity. Short-term regulation of coronary blood flow in response to metabolic stimuli is achieved via adjustment of vascular diameter in different segments of the microvasculature in conjunction with mechanical forces eliciting myogenic and flow-mediated vasodilation. In contrast, chronic adjustments in flow regulation also involve microvascular structural modifications, termed remodeling. Vascular remodeling encompasses changes in microvascular diameter and/or density being largely modulated by mechanical forces acting on the endothelium and vascular smooth muscle cells. Whereas in recent years, substantial knowledge has been gathered regarding the molecular mechanisms controlling microvascular tone and how these are altered in various diseases, the structural adaptations in response to pathologic situations are less well understood. In this article, we review the factors involved in coronary microvascular functional and structural alterations in obstructive and non-obstructive coronary artery disease and the molecular mechanisms involved therein with a focus on mechanobiology. Cardiovascular risk factors including metabolic dysregulation, hypercholesterolemia, hypertension and aging have been shown to induce microvascular (endothelial) dysfunction and vascular remodeling. Additionally, alterations in biomechanical forces produced by a coronary artery stenosis are associated with microvascular functional and structural alterations. Future studies should be directed at further unraveling the mechanisms underlying the coronary microvascular functional and structural alterations in disease; a deeper understanding of these mechanisms is critical for the identification of potential new targets for the treatment of ischemic heart disease. ?Mechanobiology of Microvascular Function and Structure in Health and D(epmc).pdf DeepDyve Pubget Overpricing