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10.7554/eLife.74589 http://scihub22266oqcxt.onion/10.7554/eLife.74589 35001872!8806188!35001872     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=35001872&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Elife 2022 ; 11 (?): ? Nephropedia Template TP {{tp|p=35001872|t=2022. Structural and functional properties of a magnesium transporter of the SLC11/NRAMP family |pdf=|usr=}}{{35001872}} gab.com Text Structural and functional properties of a magnesium transporter of the SLC11/NRAMP family JO: Elife http://www.kidney.de/pget.php?&tw=1&pmid=35001872 #FOAvip Members of the ubiquitous SLC11/NRAMP family catalyze the uptake of divalent transition metal ions into cells. They have evolved to efficiently select these trace elements from a large pool of Ca(2+) and Mg(2+), which are both orders of magnitude more abundant, and to concentrate them in the cytoplasm aided by the cotransport of H(+) serving as energy source. In the present study, we have characterized a member of a distant clade of the family found in prokaryotes, termed NRMTs, that were proposed to function as transporters of Mg(2+). The protein transports Mg(2+) and Mn(2+) but not Ca(2+) by a mechanism that is not coupled to H(+). Structures determined by cryo-EM and X-ray crystallography revealed a generally similar protein architecture compared to classical NRAMPs, with a restructured ion binding site whose increased volume provides suitable interactions with ions that likely have retained much of their hydration shell. Twit Text FOAVip Structural and functional properties of a magnesium transporter of the SLC11/NRAMP family ????Elife http://www.kidney.de/pget.php?&tw=1&pmid=35001872 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35001872 #FOAvip English Wikipedia <ref>{{Cite pmid|35001872}}</ref> Structural and functional properties of a magnesium transporter of the SLC11/NRAMP family #MMPMID35001872 Ramanadane K; Straub MS; Dutzler R; Manatschal C Elife 2022[Jan]; 11 (?): ? PMID35001872show ga Members of the ubiquitous SLC11/NRAMP family catalyze the uptake of divalent transition metal ions into cells. They have evolved to efficiently select these trace elements from a large pool of Ca(2+) and Mg(2+), which are both orders of magnitude more abundant, and to concentrate them in the cytoplasm aided by the cotransport of H(+) serving as energy source. In the present study, we have characterized a member of a distant clade of the family found in prokaryotes, termed NRMTs, that were proposed to function as transporters of Mg(2+). The protein transports Mg(2+) and Mn(2+) but not Ca(2+) by a mechanism that is not coupled to H(+). Structures determined by cryo-EM and X-ray crystallography revealed a generally similar protein architecture compared to classical NRAMPs, with a restructured ion binding site whose increased volume provides suitable interactions with ions that likely have retained much of their hydration shell. |Bacteria/*genetics/metabolism[MESH] |Cation Transport Proteins/chemistry/*genetics/metabolism[MESH]Structural and functional properties of a magnesium transporter of the(epmc).pdf DeepDyve Pubget Overpricing