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10.1016/j.preghy.2021.12.001

http://scihub22266oqcxt.onion/10.1016/j.preghy.2021.12.001
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34998223!8653398!34998223
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suck abstract from ncbi


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pmid34998223      Pregnancy+Hypertens 2022 ; 27 (ä): 103-109
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  • sFlt-1/PlGF ratio in hypertensive disorders of pregnancy in patients affected by COVID-19 #MMPMID34998223
  • Soldavini CM; Di Martino D; Sabattini E; Ornaghi S; Sterpi V; Erra R; Invernizzi F; Tine' G; Giardini V; Vergani P; Ossola MW; Ferrazzi E
  • Pregnancy Hypertens 2022[Mar]; 27 (ä): 103-109 PMID34998223show ga
  • OBJECTIVES: To analyze soluble Fms-like tyrosine Kinase 1 (sFlt-1) and Placental Growth Factor (PlGF) ratio concentrations in COVID-19 pregnant patients with and without Hypertensive Disorders of Pregnancy (HDP), compared with non COVID-19 pregnant patients with HDP and a control group. STUDY DESIGN: We recruited and obtained a complete follow-up of 19 COVID-19 pregnant patients with HDP and of 24 COVID-19 normotensive pregnant patients. Demographic, clinical and sFlt-1/PlGF ratio findings were compared with a group of 185 non COVID-19 pregnant patients with HDP and 41 non COVID normotensive patients. Findings were based on univariate analysis and on a multivariate adjusted model, and a case by case analysis of COVID-19 pregnant patients with an abnormal sFlt-1/PlGF ratio > 38 at recruitment. MAIN OUTCOME MEASURES: sFlt-1/PlGF ratio. RESULTS: We confirmed a significant higher prevalence of HDP in women affected by COVID-19 compared to control population. sFlt-1/PlGF ratio was found high in HDP patients, with and without of Sars-Cov2 infection. COVID-19 patients with worse evolution of the disease showed greater rates of obesity and other comorbidities. sFlt/PlGF ratio proved not to be helpful in the differential diagnosis of the severity of this infection. CONCLUSIONS: COVID-19 pregnant patients showed a higher prevalence of HDP compared to non COVID-19 controls, as well as higher comorbidity rates. In spite of the possible common endothelial target and damage, between Sars-Cov-2 infection and HDP, the sFlt1/PlGF ratio did not correlate with the severity of this syndrome.
  • |Adolescent[MESH]
  • |Adult[MESH]
  • |Biomarkers/blood[MESH]
  • |COVID-19/blood/*complications[MESH]
  • |Case-Control Studies[MESH]
  • |Female[MESH]
  • |Follow-Up Studies[MESH]
  • |Humans[MESH]
  • |Hypertension, Pregnancy-Induced/blood/diagnosis/*virology[MESH]
  • |Multivariate Analysis[MESH]
  • |Placenta Growth Factor/*blood[MESH]
  • |Pregnancy[MESH]
  • |Severity of Illness Index[MESH]
  • |Vascular Endothelial Growth Factor Receptor-1/*blood[MESH]


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