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  • The Role of Na(+)/K(+)-ATPase in the Development of Hyponatrenemia under Conditions of Hypoxic Stress in Patients with SARS-CoV-2 Infection #MMPMID34997875
  • Jafarova SH; Adnaev SA; Guliyeva RT; Jafar NH
  • Bull Exp Biol Med 2022[Jan]; 172 (3): 283-287 PMID34997875show ga
  • We studied laboratory parameters of patients with COVID-19 against the background of chronic pathologies (cardiovascular pathologies, obesity, type 2 diabetes melitus, and cardiovascular pathologies with allergy to statins). A decrease in pH and a shift in the electrolyte balance of blood plasma were revealed in all studied groups and were most pronounced in patients with cardiovascular pathologies with allergy to statin. It was found that low pH promotes destruction of lipid components of the erythrocyte membranes in patients with chronic pathologies, which was seen from a decrease in Na(+)/K(+)-ATPase activity and significant hyponatrenemia. In patients with cardiovascular pathologies and allergy to statins, erythrocyte membranes were most sensitive to a decrease in pH, while erythrocyte membranes of obese patients showed the greatest resistance to low pH and oxidative stress.
  • |Aged[MESH]
  • |COVID-19/*complications/metabolism[MESH]
  • |Cardiovascular Diseases/complications/metabolism/virology[MESH]
  • |Case-Control Studies[MESH]
  • |Chronic Disease[MESH]
  • |Diabetes Mellitus, Type 2/complications/metabolism/virology[MESH]
  • |Drug Hypersensitivity/complications/metabolism/virology[MESH]
  • |Erythrocyte Membrane/metabolism[MESH]
  • |Erythrocytes/metabolism[MESH]
  • |Female[MESH]
  • |Fluid Shifts/physiology[MESH]
  • |Humans[MESH]
  • |Hydrogen-Ion Concentration[MESH]
  • |Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects[MESH]
  • |Hyponatremia/*etiology/metabolism/virology[MESH]
  • |Hypoxia/*complications/metabolism[MESH]
  • |Lipid Peroxidation/physiology[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Obesity/complications/metabolism/virology[MESH]
  • |Oxidative Stress/physiology[MESH]
  • |SARS-CoV-2/physiology[MESH]
  • |Sodium-Potassium-Exchanging ATPase/*physiology[MESH]
  • |Sodium/metabolism[MESH]
  • |Stress, Physiological/physiology[MESH]

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  • suck abstract from ncbi

    283 3.172 2022