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Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Sci+Adv 2022 ; 8 (1): eabh3827 Nephropedia Template TP
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A lethal mouse model for evaluating vaccine-associated enhanced respiratory disease during SARS-CoV-2 infection #MMPMID34995117
Iwata-Yoshikawa N; Shiwa N; Sekizuka T; Sano K; Ainai A; Hemmi T; Kataoka M; Kuroda M; Hasegawa H; Suzuki T; Nagata N
Sci Adv 2022[Jan]; 8 (1): eabh3827 PMID34995117show ga
One safety concern during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine development has been the vaccine-associated enhanced disease, which is characterized by eosinophilic immunopathology and T helper cell type 2 (T(H)2)-biased immune responses with insufficient neutralizing antibodies. In this study, we established a lethal animal model using BALB/c mice and a mouse-passaged isolate (QHmusX) from a European lineage of SARS-CoV-2. The QHmusX strain induced acute respiratory illness, associated with diffuse alveolar damage and pulmonary edema, in T(H)2-prone adult BALB/c mice, but not in young mice or T(H)1-prone C57BL/6 mice. We also showed that immunization of adult BALB/c mice with recombinant spike protein without appropriate adjuvant caused eosinophilic immunopathology with T(H)2-shifted immune response and insufficient neutralizing antibodies after QHmusX infection. This lethal mouse model is useful for evaluating vaccine-associated enhanced respiratory disease during SARS-CoV-2 infection and may provide new insights into the disease pathogenesis of SARS-CoV-2.