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10.1038/s42255-021-00508-2 http://scihub22266oqcxt.onion/10.1038/s42255-021-00508-2 34992299!ä!34992299 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Metab 2022 ; 4 (1): 29-43 Nephropedia Template TP {{tp|p=34992299|t=2022. GP73 is a glucogenic hormone contributing to SARS-CoV-2-induced hyperglycemia |pdf=|usr=}}{{34992299}} gab.com Text GP73 is a glucogenic hormone contributing to SARS-CoV-2-induced hyperglycemia JO: Nat Metab http://www.kidney.de/pget.php?&tw=1&pmid=34992299 #FOAvip Severe cases of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are associated with elevated blood glucose levels and metabolic complications. However, the molecular mechanisms for how SARS-CoV-2 infection alters glycometabolic control are incompletely understood. Here, we connect the circulating protein GP73 with enhanced hepatic gluconeogenesis during SARS-CoV-2 infection. We first demonstrate that GP73 secretion is induced in multiple tissues upon fasting and that GP73 stimulates hepatic gluconeogenesis through the cAMP/PKA signaling pathway. We further show that GP73 secretion is increased in cultured cells infected with SARS-CoV-2, after overexpression of SARS-CoV-2 nucleocapsid and spike proteins and in lungs and livers of mice infected with a mouse-adapted SARS-CoV-2 strain. GP73 blockade with an antibody inhibits excessive glucogenesis stimulated by SARS-CoV-2 in vitro and lowers elevated fasting blood glucose levels in infected mice. In patients with COVID-19, plasma GP73 levels are elevated and positively correlate with blood glucose levels. Our data suggest that GP73 is a glucogenic hormone that likely contributes to SARS-CoV-2-induced abnormalities in systemic glucose metabolism. Twit Text FOAVip GP73 is a glucogenic hormone contributing to SARS-CoV-2-induced hyperglycemia ????Nat Metab http://www.kidney.de/pget.php?&tw=1&pmid=34992299 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34992299 #FOAvip English Wikipedia <ref>{{Cite pmid|34992299}}</ref> GP73 is a glucogenic hormone contributing to SARS-CoV-2-induced hyperglycemia #MMPMID34992299 Wan L; Gao Q; Deng Y; Ke Y; Ma E; Yang H; Lin H; Li H; Yang Y; Gong J; Li J; Xu Y; Liu J; Li J; Liu J; Zhang X; Huang L; Feng J; Zhang Y; Huang H; Wang H; Wang C; Chen Q; Huang X; Ye Q; Li D; Yan Q; Liu M; Wei M; Mo Y; Li D; Tang K; Lin C; Zheng F; Xu L; Cheng G; Wang P; Yang X; Wu F; Sun Z; Qin C; Wei C; Zhong H Nat Metab 2022[Jan]; 4 (1): 29-43 PMID34992299show ga Severe cases of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are associated with elevated blood glucose levels and metabolic complications. However, the molecular mechanisms for how SARS-CoV-2 infection alters glycometabolic control are incompletely understood. Here, we connect the circulating protein GP73 with enhanced hepatic gluconeogenesis during SARS-CoV-2 infection. We first demonstrate that GP73 secretion is induced in multiple tissues upon fasting and that GP73 stimulates hepatic gluconeogenesis through the cAMP/PKA signaling pathway. We further show that GP73 secretion is increased in cultured cells infected with SARS-CoV-2, after overexpression of SARS-CoV-2 nucleocapsid and spike proteins and in lungs and livers of mice infected with a mouse-adapted SARS-CoV-2 strain. GP73 blockade with an antibody inhibits excessive glucogenesis stimulated by SARS-CoV-2 in vitro and lowers elevated fasting blood glucose levels in infected mice. In patients with COVID-19, plasma GP73 levels are elevated and positively correlate with blood glucose levels. Our data suggest that GP73 is a glucogenic hormone that likely contributes to SARS-CoV-2-induced abnormalities in systemic glucose metabolism. |*SARS-CoV-2[MESH] |Animals[MESH] |Biomarkers[MESH] |COVID-19/*complications/*virology[MESH] |Cyclic AMP-Dependent Protein Kinases/metabolism[MESH] |Diet, High-Fat[MESH] |Disease Models, Animal[MESH] |Fasting[MESH] |Gene Expression[MESH] |Gluconeogenesis/drug effects/genetics[MESH] |Glucose/*metabolism[MESH] |Host-Pathogen Interactions[MESH] |Humans[MESH] |Hyperglycemia/blood/*etiology/*metabolism[MESH] |Liver/metabolism/pathology[MESH] |Membrane Proteins/antagonists & inhibitors/blood/genetics/*metabolism[MESH] |Mice[MESH] |Mice, Knockout[MESH]GP73 is a glucogenic hormone contributing to SARS-CoV-2-induced hyperg(epmc).pdf DeepDyve Pubget Overpricing