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10.1126/science.abm8143 http://scihub22266oqcxt.onion/10.1126/science.abm8143 34990214!9400459!34990214     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Science 2022 ; 375 (6579): 449-454 Nephropedia Template TP {{tp|p=34990214|t=2022. Antibody-mediated broad sarbecovirus neutralization through ACE2 molecular mimicry |pdf=|usr=}}{{34990214}} gab.com Text Antibody-mediated broad sarbecovirus neutralization through ACE2 molecular mimicry JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=34990214 #FOAvip Understanding broadly neutralizing sarbecovirus antibody responses is key to developing countermeasures against SARS-CoV-2 variants and future zoonotic sarbecoviruses. We describe the isolation and characterization of a human monoclonal antibody, designated S2K146, that broadly neutralizes viruses belonging to SARS-CoV- and SARS-CoV-2-related sarbecovirus clades which use ACE2 as an entry receptor. Structural and functional studies show that most of the virus residues that directly bind S2K146 are also involved in binding to ACE2. This allows the antibody to potently inhibit receptor attachment. S2K146 protects against SARS-CoV-2 Beta challenge in hamsters and viral passaging experiments reveal a high barrier for emergence of escape mutants, making it a good candidate for clinical development. The conserved ACE2-binding residues present a site of vulnerability that might be leveraged for developing vaccines eliciting broad sarbecovirus immunity. Twit Text FOAVip Antibody-mediated broad sarbecovirus neutralization through ACE2 molecular mimicry ????Science http://www.kidney.de/pget.php?&tw=1&pmid=34990214 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34990214 #FOAvip English Wikipedia <ref>{{Cite pmid|34990214}}</ref> Antibody-mediated broad sarbecovirus neutralization through ACE2 molecular mimicry #MMPMID34990214 Park YJ; De Marco A; Starr TN; Liu Z; Pinto D; Walls AC; Zatta F; Zepeda SK; Bowen JE; Sprouse KR; Joshi A; Giurdanella M; Guarino B; Noack J; Abdelnabi R; Foo SC; Rosen LE; Lempp FA; Benigni F; Snell G; Neyts J; Whelan SPJ; Virgin HW; Bloom JD; Corti D; Pizzuto MS; Veesler D Science 2022[Jan]; 375 (6579): 449-454 PMID34990214show ga Understanding broadly neutralizing sarbecovirus antibody responses is key to developing countermeasures against SARS-CoV-2 variants and future zoonotic sarbecoviruses. We describe the isolation and characterization of a human monoclonal antibody, designated S2K146, that broadly neutralizes viruses belonging to SARS-CoV- and SARS-CoV-2-related sarbecovirus clades which use ACE2 as an entry receptor. Structural and functional studies show that most of the virus residues that directly bind S2K146 are also involved in binding to ACE2. This allows the antibody to potently inhibit receptor attachment. S2K146 protects against SARS-CoV-2 Beta challenge in hamsters and viral passaging experiments reveal a high barrier for emergence of escape mutants, making it a good candidate for clinical development. The conserved ACE2-binding residues present a site of vulnerability that might be leveraged for developing vaccines eliciting broad sarbecovirus immunity. |Angiotensin-Converting Enzyme 2/chemistry/*metabolism[MESH] |Animals[MESH] |Antibodies, Monoclonal/chemistry/immunology/metabolism/therapeutic use[MESH] |Antibodies, Viral/chemistry/*immunology/metabolism[MESH] |Antibody Affinity[MESH] |Betacoronavirus/*immunology[MESH] |Broadly Neutralizing Antibodies/chemistry/*immunology/metabolism/therapeutic use[MESH] |COVID-19/immunology/*therapy[MESH] |Cross Reactions[MESH] |Cryoelectron Microscopy[MESH] |Epitopes[MESH] |Humans[MESH] |Immune Evasion[MESH] |Mesocricetus[MESH] |Models, Molecular[MESH] |Molecular Mimicry[MESH] |Mutation[MESH] |Protein Conformation[MESH] |Protein Domains[MESH] |Receptors, Coronavirus/chemistry/metabolism[MESH] |SARS-CoV-2/*immunology[MESH]Antibody-mediated broad sarbecovirus neutralization through ACE2 molec(epmc).pdf DeepDyve Pubget Overpricing