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10.3389/fonc.2021.765329 http://scihub22266oqcxt.onion/10.3389/fonc.2021.765329 34988012!8721045!34988012     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34988012&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Front+Oncol 2021 ; 11 (?): 765329 Nephropedia Template TP {{tp|p=34988012|t=2021. Alterations of Ion Homeostasis in Cancer Metastasis: Implications for Treatment |pdf=|usr=}}{{34988012}} gab.com Text Alterations of Ion Homeostasis in Cancer Metastasis: Implications for Treatment JO: Front Oncol http://www.kidney.de/pget.php?&tw=1&pmid=34988012 #FOAvip We have previously reported that metastases from all malignancies are characterized by a core program of gene expression that suppresses extracellular matrix interactions, induces vascularization/tissue remodeling, activates the oxidative metabolism, and alters ion homeostasis. Among these features, the least elucidated component is ion homeostasis. Here we review the literature with the goal to infer a better mechanistic understanding of the progression-associated ionic alterations and identify the most promising drugs for treatment. Cancer metastasis is accompanied by skewing in calcium, zinc, copper, potassium, sodium and chloride homeostasis. Membrane potential changes and water uptake through Aquaporins may also play roles. Drug candidates to reverse these alterations are at various stages of testing, with some having entered clinical trials. Challenges to their utilization comprise differences among tumor types and the involvement of multiple ions in each case. Further, adverse effects may become a concern, as channel blockers, chelators, or supplemented ions will affect healthy and transformed cells alike. Twit Text FOAVip Alterations of Ion Homeostasis in Cancer Metastasis: Implications for Treatment ????Front Oncol http://www.kidney.de/pget.php?&tw=1&pmid=34988012 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34988012 #FOAvip English Wikipedia <ref>{{Cite pmid|34988012}}</ref> Alterations of Ion Homeostasis in Cancer Metastasis: Implications for Treatment #MMPMID34988012 Fnu G; Weber GF Front Oncol 2021[]; 11 (?): 765329 PMID34988012show ga We have previously reported that metastases from all malignancies are characterized by a core program of gene expression that suppresses extracellular matrix interactions, induces vascularization/tissue remodeling, activates the oxidative metabolism, and alters ion homeostasis. Among these features, the least elucidated component is ion homeostasis. Here we review the literature with the goal to infer a better mechanistic understanding of the progression-associated ionic alterations and identify the most promising drugs for treatment. Cancer metastasis is accompanied by skewing in calcium, zinc, copper, potassium, sodium and chloride homeostasis. Membrane potential changes and water uptake through Aquaporins may also play roles. Drug candidates to reverse these alterations are at various stages of testing, with some having entered clinical trials. Challenges to their utilization comprise differences among tumor types and the involvement of multiple ions in each case. Further, adverse effects may become a concern, as channel blockers, chelators, or supplemented ions will affect healthy and transformed cells alike. ?Alterations of Ion Homeostasis in Cancer Metastasis: Implications for (epmc).pdf DeepDyve Pubget Overpricing