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suck abstract from ncbi

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  • The Type 2 Asthma Mediator IL-13 Inhibits Severe Acute Respiratory Syndrome Coronavirus 2 Infection of Bronchial Epithelium #MMPMID34982656
  • Bonser LR; Eckalbar WL; Rodriguez L; Shen J; Koh KD; Ghias K; Zlock LT; Christenson S; Woodruff PG; Finkbeiner WE; Erle DJ
  • Am J Respir Cell Mol Biol 2022[Apr]; 66 (4): 391-401 PMID34982656show ga
  • Asthma is associated with chronic changes in the airway epithelium, a key target of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Many epithelial changes, including goblet cell metaplasia, are driven by the type 2 cytokine IL-13, but the effects of IL-13 on SARS-CoV-2 infection are unknown. We found that IL-13 stimulation of differentiated human bronchial epithelial cells (HBECs) cultured at air-liquid interface reduced viral RNA recovered from SARS-CoV-2-infected cells and decreased double-stranded RNA, a marker of viral replication, to below the limit of detection in our assay. An intact mucus gel reduced SARS-CoV-2 infection of unstimulated cells, but neither a mucus gel nor SPDEF, which is required for goblet cell metaplasia, were required for the antiviral effects of IL-13. Bulk RNA sequencing revealed that IL-13 regulated 41 of 332 (12%) mRNAs encoding SARS-CoV-2-associated proteins that were detected in HBECs (>1.5-fold change; false discovery rate < 0.05). Although both IL-13 and IFN-alpha each inhibit SARS-CoV-2 infection, their transcriptional effects differed markedly. Single-cell RNA sequencing revealed cell type-specific differences in SARS-CoV-2-associated gene expression and IL-13 responses. Many IL-13-induced gene expression changes were seen in airway epithelium from individuals with type 2 asthma and chronic obstructive pulmonary disease. IL-13 effects on airway epithelial cells may protect individuals with type 2 asthma from COVID-19 and could lead to identification of novel strategies for reducing SARS-CoV-2 infection.
  • |*Asthma[MESH]
  • |*COVID-19[MESH]
  • |Cells, Cultured[MESH]
  • |Epithelial Cells[MESH]
  • |Epithelium[MESH]
  • |Humans[MESH]
  • |Interleukin-13/pharmacology[MESH]
  • |SARS-CoV-2[MESH]

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  • suck abstract from ncbi

    391 4.66 2022