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10.1002/cphc.202100704 http://scihub22266oqcxt.onion/10.1002/cphc.202100704 34968005!9015374!34968005     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Chemphyschem 2022 ; 23 (4): e202100704 Nephropedia Template TP {{tp|p=34968005|t=2022. The Extended Hadamard Transform: Sensitivity-Enhanced NMR Experiments Among Labile and Non-Labile (1) Hs of SARS-CoV-2-derived RNAs |pdf=|usr=}}{{34968005}} gab.com Text The Extended Hadamard Transform: Sensitivity-Enhanced NMR Experiments Among Labile and Non-Labile (1) Hs of SARS-CoV-2-derived RNAs JO: Chemphyschem http://www.kidney.de/pget.php?&tw=1&pmid=34968005 #FOAvip Hadamard encoded saturation transfer can significantly improve the efficiency of NOE-based NMR correlations from labile protons in proteins, glycans and RNAs, increasing the sensitivity of cross-peaks by an order of magnitude and shortening experimental times by >/=100-fold. These schemes, however, fail when tackling correlations within a pool of labile protons - for instance imino-imino correlations in RNAs or amide-amide correlations in proteins. Here we analyze the origin of the artifacts appearing in these experiments and propose a way to obtain artifact-free correlations both within the labile pool as well as between labile and non-labile (1) Hs, while still enjoying the gains arising from Hadamard encoding and solvent repolarizations. The principles required for implementing what we define as the extended Hadamard scheme are derived, and its clean, artifact-free, sensitivity-enhancing performance is demonstrated on RNA fragments derived from the SARS-CoV-2 genome. Sensitivity gains per unit time approaching an order of magnitude are then achieved in both imino-imino and imino-amino/aromatic protons 2D correlations; similar artifact-free sensitivity gains can be observed when carrying out extended Hadamard encodings of 3D NOESY/HSQC-type experiments. The resulting spectra reveal significantly more correlations than their conventionally acquired counterparts, which can support the spectral assignment and secondary structure determination of structured RNA elements. Twit Text FOAVip The Extended Hadamard Transform: Sensitivity-Enhanced NMR Experiments Among Labile and Non-Labile (1) Hs of SARS-CoV-2-derived RNAs ????Chemphyschem http://www.kidney.de/pget.php?&tw=1&pmid=34968005 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34968005 #FOAvip English Wikipedia <ref>{{Cite pmid|34968005}}</ref> The Extended Hadamard Transform: Sensitivity-Enhanced NMR Experiments Among Labile and Non-Labile (1) Hs of SARS-CoV-2-derived RNAs #MMPMID34968005 Kim J; Novakovic M; Jayanthi S; Lupulescu A; Kupce E; Grun JT; Mertinkus K; Oxenfarth A; Schwalbe H; Frydman L Chemphyschem 2022[Feb]; 23 (4): e202100704 PMID34968005show ga Hadamard encoded saturation transfer can significantly improve the efficiency of NOE-based NMR correlations from labile protons in proteins, glycans and RNAs, increasing the sensitivity of cross-peaks by an order of magnitude and shortening experimental times by >/=100-fold. These schemes, however, fail when tackling correlations within a pool of labile protons - for instance imino-imino correlations in RNAs or amide-amide correlations in proteins. Here we analyze the origin of the artifacts appearing in these experiments and propose a way to obtain artifact-free correlations both within the labile pool as well as between labile and non-labile (1) Hs, while still enjoying the gains arising from Hadamard encoding and solvent repolarizations. The principles required for implementing what we define as the extended Hadamard scheme are derived, and its clean, artifact-free, sensitivity-enhancing performance is demonstrated on RNA fragments derived from the SARS-CoV-2 genome. Sensitivity gains per unit time approaching an order of magnitude are then achieved in both imino-imino and imino-amino/aromatic protons 2D correlations; similar artifact-free sensitivity gains can be observed when carrying out extended Hadamard encodings of 3D NOESY/HSQC-type experiments. The resulting spectra reveal significantly more correlations than their conventionally acquired counterparts, which can support the spectral assignment and secondary structure determination of structured RNA elements. |*COVID-19[MESH] |*SARS-CoV-2[MESH] |Humans[MESH] |Magnetic Resonance Spectroscopy/methods[MESH] |Proteins/chemistry[MESH]The Extended Hadamard Transform: Sensitivity-Enhanced NMR Experiments (epmc).pdf DeepDyve Pubget Overpricing