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10.1016/j.chom.2021.12.005

http://scihub22266oqcxt.onion/10.1016/j.chom.2021.12.005
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suck abstract from ncbi


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pmid34965382      Cell+Host+Microbe 2022 ; 30 (1): 83-96.e4
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  • Pre-existing humoral immunity to human common cold coronaviruses negatively impacts the protective SARS-CoV-2 antibody response #MMPMID34965382
  • Lin CY; Wolf J; Brice DC; Sun Y; Locke M; Cherry S; Castellaw AH; Wehenkel M; Crawford JC; Zarnitsyna VI; Duque D; Allison KJ; Allen EK; Brown SA; Mandarano AH; Estepp JH; Taylor C; Molina-Paris C; Schultz-Cherry S; Tang L; Thomas PG; McGargill MA
  • Cell Host Microbe 2022[Jan]; 30 (1): 83-96.e4 PMID34965382show ga
  • SARS-CoV-2 infection causes diverse outcomes ranging from asymptomatic infection to respiratory distress and death. A major unresolved question is whether prior immunity to endemic, human common cold coronaviruses (hCCCoVs) impacts susceptibility to SARS-CoV-2 infection or immunity following infection and vaccination. Therefore, we analyzed samples from the same individuals before and after SARS-CoV-2 infection or vaccination. We found hCCCoV antibody levels increase after SARS-CoV-2 exposure, demonstrating cross-reactivity. However, a case-control study indicates that baseline hCCCoV antibody levels are not associated with protection against SARS-CoV-2 infection. Rather, higher magnitudes of pre-existing betacoronavirus antibodies correlate with more SARS-CoV-2 antibodies following infection, an indicator of greater disease severity. Additionally, immunization with hCCCoV spike proteins before SARS-CoV-2 immunization impedes the generation of SARS-CoV-2-neutralizing antibodies in mice. Together, these data suggest that pre-existing hCCCoV antibodies hinder SARS-CoV-2 antibody-based immunity following infection and provide insight on how pre-existing coronavirus immunity impacts SARS-CoV-2 infection, which is critical considering emerging variants.
  • |Animals[MESH]
  • |Antibodies, Viral/*immunology[MESH]
  • |Antibody Formation/*immunology[MESH]
  • |Asymptomatic Infections[MESH]
  • |COVID-19/*immunology/virology[MESH]
  • |Case-Control Studies[MESH]
  • |Cell Line[MESH]
  • |Common Cold/*immunology/virology[MESH]
  • |Cross Reactions/immunology[MESH]
  • |Female[MESH]
  • |HEK293 Cells[MESH]
  • |Humans[MESH]
  • |Immunity, Humoral/*immunology[MESH]
  • |Mice[MESH]
  • |Mice, Inbred C57BL[MESH]
  • |SARS-CoV-2/*immunology[MESH]


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