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10.1172/JCI150101

http://scihub22266oqcxt.onion/10.1172/JCI150101
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34964720!8843740!34964720
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suck abstract from ncbi


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pmid34964720      J+Clin+Invest 2022 ; 132 (4): ä
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  • Platelets mediate inflammatory monocyte activation by SARS-CoV-2 spike protein #MMPMID34964720
  • Li T; Yang Y; Li Y; Wang Z; Ma F; Luo R; Xu X; Zhou G; Wang J; Niu J; Lv G; Crispe IN; Tu Z
  • J Clin Invest 2022[Feb]; 132 (4): ä PMID34964720show ga
  • Infection with SARS-CoV-2, the causative agent of COVID-19, causes mild to moderate disease in most patients but carries a risk of morbidity and mortality. Seriously affected individuals manifest disorders of hemostasis and a cytokine storm, but it is not understood how these manifestations of severe COVID-19 are linked. Here, we showed that the SARS-CoV-2 spike protein engaged the CD42b receptor to activate platelets via 2 distinct signaling pathways and promoted platelet-monocyte communication through the engagement of P selectin/PGSL-1 and CD40L/CD40, which led to proinflammatory cytokine production by monocytes. These results explain why hypercoagulation, monocyte activation, and a cytokine storm are correlated in patients severely affected by COVID-19 and suggest a potential target for therapeutic intervention.
  • |*SARS-CoV-2[MESH]
  • |Blood Platelets/metabolism/*physiology[MESH]
  • |CD40 Antigens/blood[MESH]
  • |CD40 Ligand/blood[MESH]
  • |COVID-19/*blood[MESH]
  • |Cell Communication[MESH]
  • |Cytokine Release Syndrome[MESH]
  • |Cytokines[MESH]
  • |HEK293 Cells[MESH]
  • |Humans[MESH]
  • |Inflammation/*blood[MESH]
  • |Monocytes/*metabolism[MESH]
  • |P-Selectin/blood[MESH]


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