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10.1172/JCI150101 http://scihub22266oqcxt.onion/10.1172/JCI150101 34964720!8843740!34964720     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34964720&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\34964720.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Clin+Invest 2022 ; 132 (4): ä Nephropedia Template TP {{tp|p=34964720|t=2022. Platelets mediate inflammatory monocyte activation by SARS-CoV-2 spike protein |pdf=|usr=}}{{34964720}} gab.com Text Platelets mediate inflammatory monocyte activation by SARS-CoV-2 spike protein JO: J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=34964720 #FOAvip Infection with SARS-CoV-2, the causative agent of COVID-19, causes mild to moderate disease in most patients but carries a risk of morbidity and mortality. Seriously affected individuals manifest disorders of hemostasis and a cytokine storm, but it is not understood how these manifestations of severe COVID-19 are linked. Here, we showed that the SARS-CoV-2 spike protein engaged the CD42b receptor to activate platelets via 2 distinct signaling pathways and promoted platelet-monocyte communication through the engagement of P selectin/PGSL-1 and CD40L/CD40, which led to proinflammatory cytokine production by monocytes. These results explain why hypercoagulation, monocyte activation, and a cytokine storm are correlated in patients severely affected by COVID-19 and suggest a potential target for therapeutic intervention. Twit Text FOAVip Platelets mediate inflammatory monocyte activation by SARS-CoV-2 spike protein ????J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=34964720 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34964720 #FOAvip English Wikipedia <ref>{{Cite pmid|34964720}}</ref> Platelets mediate inflammatory monocyte activation by SARS-CoV-2 spike protein #MMPMID34964720 Li T; Yang Y; Li Y; Wang Z; Ma F; Luo R; Xu X; Zhou G; Wang J; Niu J; Lv G; Crispe IN; Tu Z J Clin Invest 2022[Feb]; 132 (4): ä PMID34964720show ga Infection with SARS-CoV-2, the causative agent of COVID-19, causes mild to moderate disease in most patients but carries a risk of morbidity and mortality. Seriously affected individuals manifest disorders of hemostasis and a cytokine storm, but it is not understood how these manifestations of severe COVID-19 are linked. Here, we showed that the SARS-CoV-2 spike protein engaged the CD42b receptor to activate platelets via 2 distinct signaling pathways and promoted platelet-monocyte communication through the engagement of P selectin/PGSL-1 and CD40L/CD40, which led to proinflammatory cytokine production by monocytes. These results explain why hypercoagulation, monocyte activation, and a cytokine storm are correlated in patients severely affected by COVID-19 and suggest a potential target for therapeutic intervention. |*SARS-CoV-2[MESH] |Blood Platelets/metabolism/*physiology[MESH] |CD40 Antigens/blood[MESH] |CD40 Ligand/blood[MESH] |COVID-19/*blood[MESH] |Cell Communication[MESH] |Cytokine Release Syndrome[MESH] |Cytokines[MESH] |HEK293 Cells[MESH] |Humans[MESH] |Inflammation/*blood[MESH] |Monocytes/*metabolism[MESH] |P-Selectin/blood[MESH]Platelets mediate inflammatory monocyte activation by SARS-CoV-2 spike(epmc).pdf DeepDyve Pubget Overpricing