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10.1093/bib/bbab507 http://scihub22266oqcxt.onion/10.1093/bib/bbab507 34962256!8769897!34962256     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Brief+Bioinform 2022 ; 23 (1): ä Nephropedia Template TP {{tp|p=34962256|t=2022. Computationally prioritized drugs inhibit SARS-CoV-2 infection and syncytia formation |pdf=|usr=}}{{34962256}} gab.com Text Computationally prioritized drugs inhibit SARS-CoV-2 infection and syncytia formation JO: Brief Bioinform http://www.kidney.de/pget.php?&tw=1&pmid=34962256 #FOAvip The pharmacological arsenal against the COVID-19 pandemic is largely based on generic anti-inflammatory strategies or poorly scalable solutions. Moreover, as the ongoing vaccination campaign is rolling slower than wished, affordable and effective therapeutics are needed. To this end, there is increasing attention toward computational methods for drug repositioning and de novo drug design. Here, multiple data-driven computational approaches are systematically integrated to perform a virtual screening and prioritize candidate drugs for the treatment of COVID-19. From the list of prioritized drugs, a subset of representative candidates to test in human cells is selected. Two compounds, 7-hydroxystaurosporine and bafetinib, show synergistic antiviral effects in vitro and strongly inhibit viral-induced syncytia formation. Moreover, since existing drug repositioning methods provide limited usable information for de novo drug design, the relevant chemical substructures of the identified drugs are extracted to provide a chemical vocabulary that may help to design new effective drugs. Twit Text FOAVip Computationally prioritized drugs inhibit SARS-CoV-2 infection and syncytia formation ????Brief Bioinform http://www.kidney.de/pget.php?&tw=1&pmid=34962256 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34962256 #FOAvip English Wikipedia <ref>{{Cite pmid|34962256}}</ref> Computationally prioritized drugs inhibit SARS-CoV-2 infection and syncytia formation #MMPMID34962256 Serra A; Fratello M; Federico A; Ojha R; Provenzani R; Tasnadi E; Cattelani L; Del Giudice G; Kinaret PAS; Saarimaki LA; Pavel A; Kuivanen S; Cerullo V; Vapalahti O; Horvath P; Lieto AD; Yli-Kauhaluoma J; Balistreri G; Greco D Brief Bioinform 2022[Jan]; 23 (1): ä PMID34962256show ga The pharmacological arsenal against the COVID-19 pandemic is largely based on generic anti-inflammatory strategies or poorly scalable solutions. Moreover, as the ongoing vaccination campaign is rolling slower than wished, affordable and effective therapeutics are needed. To this end, there is increasing attention toward computational methods for drug repositioning and de novo drug design. Here, multiple data-driven computational approaches are systematically integrated to perform a virtual screening and prioritize candidate drugs for the treatment of COVID-19. From the list of prioritized drugs, a subset of representative candidates to test in human cells is selected. Two compounds, 7-hydroxystaurosporine and bafetinib, show synergistic antiviral effects in vitro and strongly inhibit viral-induced syncytia formation. Moreover, since existing drug repositioning methods provide limited usable information for de novo drug design, the relevant chemical substructures of the identified drugs are extracted to provide a chemical vocabulary that may help to design new effective drugs. |*COVID-19 Drug Treatment[MESH] |*COVID-19/metabolism[MESH] |*Giant Cells/metabolism/virology[MESH] |A549 Cells[MESH] |Antiviral Agents/*pharmacology[MESH] |Computational Biology[MESH] |Drug Evaluation, Preclinical[MESH] |Drug Repositioning[MESH] |Humans[MESH] |Pyrimidines/*pharmacology[MESH] |SARS-CoV-2/*metabolism[MESH]Computationally prioritized drugs inhibit SARS-CoV-2 infection and syn(epmc).pdf DeepDyve Pubget Overpricing