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10.3390/v13122456

http://scihub22266oqcxt.onion/10.3390/v13122456
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34960725!8706135!34960725
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suck abstract from ncbi


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pmid34960725      Viruses 2021 ; 13 (12): ä
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  • Plasma Proteome Fingerprints Reveal Distinctiveness and Clinical Outcome of SARS-CoV-2 Infection #MMPMID34960725
  • Bauer W; Weber M; Diehl-Wiesenecker E; Galtung N; Prpic M; Somasundaram R; Tauber R; Schwenk JM; Micke P; Kappert K
  • Viruses 2021[Dec]; 13 (12): ä PMID34960725show ga
  • BACKGROUND: We evaluated how plasma proteomic signatures in patients with suspected COVID-19 can unravel the pathophysiology, and determine kinetics and clinical outcome of the infection. METHODS: Plasma samples from patients presenting to the emergency department (ED) with symptoms of COVID-19 were stratified into: (1) patients with suspected COVID-19 that was not confirmed (n = 44); (2) non-hospitalized patients with confirmed COVID-19 (n = 44); (3) hospitalized patients with confirmed COVID-19 (n = 53) with variable outcome; and (4) patients presenting to the ED with minor diseases unrelated to SARS-CoV-2 infection (n = 20). Besides standard of care diagnostics, 177 circulating proteins related to inflammation and cardiovascular disease were analyzed using proximity extension assay (PEA, Olink) technology. RESULTS: Comparative proteome analysis revealed 14 distinct proteins as highly associated with SARS-CoV-2 infection and 12 proteins with subsequent hospitalization (p < 0.001). ADM, IL-6, MCP-3, TRAIL-R2, and PD-L1 were each predictive for death (AUROC curve 0.80-0.87). The consistent increase of these markers, from hospital admission to intensive care and fatality, supported the concept that these proteins are of major clinical relevance. CONCLUSIONS: We identified distinct plasma proteins linked to the presence and course of COVID-19. These plasma proteomic findings may translate to a protein fingerprint, helping to assist clinical management decisions.
  • |*Proteome[MESH]
  • |Berlin[MESH]
  • |Biomarkers/*blood[MESH]
  • |Blood Proteins[MESH]
  • |COVID-19 Drug Treatment[MESH]
  • |COVID-19/*blood[MESH]
  • |Emergency Medicine[MESH]
  • |Emergency Service, Hospital[MESH]
  • |Hospitalization[MESH]
  • |Humans[MESH]
  • |Plasma/*metabolism[MESH]
  • |Proteomics[MESH]


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