Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.3390/v13122379 http://scihub22266oqcxt.onion/10.3390/v13122379 34960648!8704679!34960648     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Viruses 2021 ; 13 (12): ä Nephropedia Template TP {{tp|p=34960648|t=2021. JAK-STAT Pathway: A Novel Target to Tackle Viral Infections |pdf=|usr=}}{{34960648}} gab.com Text JAK-STAT Pathway: A Novel Target to Tackle Viral Infections JO: Viruses http://www.kidney.de/pget.php?&tw=1&pmid=34960648 #FOAvip Modulation of the antiviral innate immune response has been proposed as a putative cellular target for the development of novel pan-viral therapeutic strategies. The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway is especially relevant due to its essential role in the regulation of local and systemic inflammation in response to viral infections, being, therefore, a putative therapeutic target. Here, we review the extraordinary diversity of strategies that viruses have evolved to interfere with JAK-STAT signaling, stressing the relevance of this pathway as a putative antiviral target. Moreover, due to the recent remarkable progress on the development of novel JAK inhibitors (JAKi), the current knowledge on its efficacy against distinct viral infections is also discussed. JAKi have a proven efficacy against a broad spectrum of disorders and exhibit safety profiles comparable to biologics, therefore representing good candidates for drug repurposing strategies, including viral infections. Twit Text FOAVip JAK-STAT Pathway: A Novel Target to Tackle Viral Infections ????Viruses http://www.kidney.de/pget.php?&tw=1&pmid=34960648 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34960648 #FOAvip English Wikipedia <ref>{{Cite pmid|34960648}}</ref> JAK-STAT Pathway: A Novel Target to Tackle Viral Infections #MMPMID34960648 Ezeonwumelu IJ; Garcia-Vidal E; Ballana E Viruses 2021[Nov]; 13 (12): ä PMID34960648show ga Modulation of the antiviral innate immune response has been proposed as a putative cellular target for the development of novel pan-viral therapeutic strategies. The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway is especially relevant due to its essential role in the regulation of local and systemic inflammation in response to viral infections, being, therefore, a putative therapeutic target. Here, we review the extraordinary diversity of strategies that viruses have evolved to interfere with JAK-STAT signaling, stressing the relevance of this pathway as a putative antiviral target. Moreover, due to the recent remarkable progress on the development of novel JAK inhibitors (JAKi), the current knowledge on its efficacy against distinct viral infections is also discussed. JAKi have a proven efficacy against a broad spectrum of disorders and exhibit safety profiles comparable to biologics, therefore representing good candidates for drug repurposing strategies, including viral infections. |Antiviral Agents/pharmacology/therapeutic use[MESH] |Humans[MESH] |Immunity, Innate[MESH] |Inflammation[MESH] |Janus Kinase Inhibitors/pharmacology/therapeutic use[MESH] |Janus Kinases/antagonists & inhibitors/*metabolism[MESH] |STAT Transcription Factors/*metabolism[MESH] |Signal Transduction/*drug effects[MESH] |Virus Diseases/drug therapy/immunology/*metabolism[MESH]JAK-STAT Pathway: A Novel Target to Tackle Viral Infections (epmc).pdf DeepDyve Pubget Overpricing