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10.3390/vaccines9121503 http://scihub22266oqcxt.onion/10.3390/vaccines9121503 34960249!8703557!34960249     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Vaccines+(Basel) 2021 ; 9 (12): ä Nephropedia Template TP {{tp|p=34960249|t=2021. mRNA COVID-19 Vaccines and Long-Lived Plasma Cells: A Complicated Relationship |pdf=|usr=}}{{34960249}} gab.com Text mRNA COVID-19 Vaccines and Long-Lived Plasma Cells: A Complicated Relationship JO: Vaccines (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=34960249 #FOAvip mRNA COVID-19 vaccines have hegemonized the world market, and their administration to the population promises to stop the pandemic. However, the waning of the humoral immune response, which does not seem to last so many months after the completion of the vaccination program, has led us to study the molecular immunological mechanisms of waning immunity in the case of mRNA COVID-19 vaccines. We consulted the published scientific literature and from the few articles we found, we were convinced that there is an immunological memory problem after vaccination. Although mRNA vaccines have been demonstrated to induce antigen-specific memory B cells (MBCs) in the human population, there is no evidence that these vaccines induce the production of long-lived plasma cells (LLPCs), in a SARS-CoV-2 virus naive population. This obstacle, in our point of view, is caused by the presence, in almost all subjects, of a cellular T and B cross-reactive memory produced during past exposures to the common cold coronaviruses. Due to this interference, it is difficult for a vaccination with the Spike protein alone, without adjuvants capable of prolonging the late phase of the generation of the immunological memory, to be able to determine the production of protective LLPCs. This would explain the possibility of previously and completely vaccinated subjects to become infected, already 4-6 months after the completion of the vaccination cycle. Twit Text FOAVip mRNA COVID-19 Vaccines and Long-Lived Plasma Cells: A Complicated Relationship ????Vaccines (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=34960249 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34960249 #FOAvip English Wikipedia <ref>{{Cite pmid|34960249}}</ref> mRNA COVID-19 Vaccines and Long-Lived Plasma Cells: A Complicated Relationship #MMPMID34960249 Giannotta G; Giannotta N Vaccines (Basel) 2021[Dec]; 9 (12): ä PMID34960249show ga mRNA COVID-19 vaccines have hegemonized the world market, and their administration to the population promises to stop the pandemic. However, the waning of the humoral immune response, which does not seem to last so many months after the completion of the vaccination program, has led us to study the molecular immunological mechanisms of waning immunity in the case of mRNA COVID-19 vaccines. We consulted the published scientific literature and from the few articles we found, we were convinced that there is an immunological memory problem after vaccination. Although mRNA vaccines have been demonstrated to induce antigen-specific memory B cells (MBCs) in the human population, there is no evidence that these vaccines induce the production of long-lived plasma cells (LLPCs), in a SARS-CoV-2 virus naive population. This obstacle, in our point of view, is caused by the presence, in almost all subjects, of a cellular T and B cross-reactive memory produced during past exposures to the common cold coronaviruses. Due to this interference, it is difficult for a vaccination with the Spike protein alone, without adjuvants capable of prolonging the late phase of the generation of the immunological memory, to be able to determine the production of protective LLPCs. This would explain the possibility of previously and completely vaccinated subjects to become infected, already 4-6 months after the completion of the vaccination cycle. ämRNA COVID-19 Vaccines and Long-Lived Plasma Cells: A Complicated Rela(epmc).pdf DeepDyve Pubget Overpricing