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10.3390/vaccines9121464

http://scihub22266oqcxt.onion/10.3390/vaccines9121464
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34960211!8707647!34960211
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suck abstract from ncbi

pmid34960211      Vaccines+(Basel) 2021 ; 9 (12): ä
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  • mRNA Vaccine Protects against Zika Virus #MMPMID34960211
  • Medina-Magues LG; Gergen J; Jasny E; Petsch B; Lopera-Madrid J; Medina-Magues ES; Salas-Quinchucua C; Osorio JE
  • Vaccines (Basel) 2021[Dec]; 9 (12): ä PMID34960211show ga
  • Zika virus (ZIKV), a mosquito-borne flavivirus, has recently triggered global concern due to severe health complications. In 2015, a large ZIKV outbreak occurred in the Americas and established a link between ZIKV and microcephaly in newborn babies, spontaneous abortion, persistent viremia, and Guillain-Barre syndrome. While antivirals are being developed and prevention strategies focus on vector control, a safe and effective Zika vaccine remains unavailable. Messenger RNA (mRNA) vaccine technology has arisen as a flexible, simplified, and fast vaccine production platform. Here, we report on an mRNA vaccine candidate that encodes the pre-membrane and envelope (prM-E) glycoproteins of ZIKV strain Brazil SPH2015 and is encapsulated in lipid nanoparticles (LNPs). Our ZIKV prM-E mRNA-LNP vaccine candidate induced antibody responses that protected in AG129 mice deficient in interferon (IFN) alpha/beta/gamma (IFN-alpha/beta/gamma) receptors. Notably, a single administration of ZIKV prM-E mRNA-LNP protected against a lethal dose of ZIKV, while a two-dose strategy induced strong protective immunity. E-specific double-positive IFN-gamma and TNF-alpha T-cells were induced in BALB/c mice after immunizations with a two-dose strategy. With the success of mRNA vaccine technology in facing the coronavirus (COVID-19) pandemic, our data support the development of prM-E RNActive((R)) as a promising mRNA vaccine against Zika to counter future epidemics.
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