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10.3390/vaccines9121416

http://scihub22266oqcxt.onion/10.3390/vaccines9121416
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34960163!8706244!34960163
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suck abstract from ncbi


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pmid34960163      Vaccines+(Basel) 2021 ; 9 (12): ä
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  • Oral Administration of Coronavirus Spike Protein Provides Protection to Newborn Pigs When Challenged with PEDV #MMPMID34960163
  • Maj M; Fake GM; Walker JH; Saltzman R; Howard JA
  • Vaccines (Basel) 2021[Nov]; 9 (12): ä PMID34960163show ga
  • To investigate whether oral administration of maize-produced S antigen can provide passive immunity to piglets against porcine epidemic diarrhea virus (PEDV), 16 pregnant sows were randomly assigned to one of four treatments: (1) injection of PEDV vaccine (INJ), (2) maize grain without S protein (CON), (3) maize grain containing low dose of S antigen (LOV) and (4) maize grain containing a high dose of S antigen (HOV). Vaccines were administered on days 57, 85 and 110 of gestation. Sows' serum and colostrum were collected at farrowing and milk on day 6 post-challenge to quantify neutralizing antibodies (NABs) and cytokines. Piglets were challenged with PEDV 3-5 d after farrowing, and severity of disease and mortality assessed on day 11 post-challenge. Disease severity was lower in LOV and INJ compared with HOV and CON, whereas the survival rate increased in piglets from LOV sows compared with HOV and CON (p
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