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10.3390/cells10123537 http://scihub22266oqcxt.onion/10.3390/cells10123537 34944044!8700256!34944044     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34944044&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Cells 2021 ; 10 (12): ? Nephropedia Template TP {{tp|p=34944044|t=2021. Ion Channels and Pumps in Autophagy: A Reciprocal Relationship |pdf=|usr=}}{{34944044}} gab.com Text Ion Channels and Pumps in Autophagy: A Reciprocal Relationship JO: Cells http://www.kidney.de/pget.php?&tw=1&pmid=34944044 #FOAvip Autophagy, the process of cellular self-degradation, is intrinsically tied to the degradative function of the lysosome. Several diseases have been linked to lysosomal degradative defects, including rare lysosomal storage disorders and neurodegenerative diseases. Ion channels and pumps play a major regulatory role in autophagy. Importantly, calcium signaling produced by TRPML1 (transient receptor potential cation channel, mucolipin subfamily) has been shown to regulate autophagic progression through biogenesis of autophagic-lysosomal organelles, activation of mTORC1 (mechanistic target of rapamycin complex 1) and degradation of autophagic cargo. ER calcium channels such as IP(3)Rs supply calcium for the lysosome, and lysosomal function is severely disrupted in the absence of lysosomal calcium replenishment by the ER. TRPML1 function is also regulated by LC3 (microtubule-associated protein light chain 3) and mTORC1, two critical components of the autophagic network. Here we provide an overview of the current knowledge about ion channels and pumps-including lysosomal V-ATPase (vacuolar proton-ATPase), which is required for acidification and hence proper enzymatic activity of lysosomal hydrolases-in the regulation of autophagy, and discuss how functional impairment of some of these leads to diseases. Twit Text FOAVip Ion Channels and Pumps in Autophagy: A Reciprocal Relationship ????Cells http://www.kidney.de/pget.php?&tw=1&pmid=34944044 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34944044 #FOAvip English Wikipedia <ref>{{Cite pmid|34944044}}</ref> Ion Channels and Pumps in Autophagy: A Reciprocal Relationship #MMPMID34944044 Abuammar H; Bhattacharjee A; Simon-Vecsei Z; Blastyak A; Csordas G; Pali T; Juhasz G Cells 2021[Dec]; 10 (12): ? PMID34944044show ga Autophagy, the process of cellular self-degradation, is intrinsically tied to the degradative function of the lysosome. Several diseases have been linked to lysosomal degradative defects, including rare lysosomal storage disorders and neurodegenerative diseases. Ion channels and pumps play a major regulatory role in autophagy. Importantly, calcium signaling produced by TRPML1 (transient receptor potential cation channel, mucolipin subfamily) has been shown to regulate autophagic progression through biogenesis of autophagic-lysosomal organelles, activation of mTORC1 (mechanistic target of rapamycin complex 1) and degradation of autophagic cargo. ER calcium channels such as IP(3)Rs supply calcium for the lysosome, and lysosomal function is severely disrupted in the absence of lysosomal calcium replenishment by the ER. TRPML1 function is also regulated by LC3 (microtubule-associated protein light chain 3) and mTORC1, two critical components of the autophagic network. Here we provide an overview of the current knowledge about ion channels and pumps-including lysosomal V-ATPase (vacuolar proton-ATPase), which is required for acidification and hence proper enzymatic activity of lysosomal hydrolases-in the regulation of autophagy, and discuss how functional impairment of some of these leads to diseases. |*Autophagy[MESH] |Calcium/metabolism[MESH] |Humans[MESH] |Ion Channels/*metabolism[MESH] |Lysosomes/metabolism[MESH] |Models, Biological[MESH]Ion Channels and Pumps in Autophagy: A Reciprocal Relationship (epmc).pdf DeepDyve Pubget Overpricing