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10.1002/jmv.27539 http://scihub22266oqcxt.onion/10.1002/jmv.27539 34936124!ä!34936124 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34936124&cmd=llinks): Failed to open stream: HTTP request failed! 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Roles of the polybasic furin cleavage site of spike protein in SARS-CoV-2 replication, pathogenesis, and host immune responses and vaccination |pdf=|usr=}}{{34936124}} gab.com Text Roles of the polybasic furin cleavage site of spike protein in SARS-CoV-2 replication, pathogenesis, and host immune responses and vaccination JO: J Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=34936124 #FOAvip The polybasic furin cleavage site insertion with four amino acid motifs (PRRA) in spike protein's S1/S2 junction site is important in determining viral infectivity, transmission, and host range. However, there is no review so far explaining the effect of the furin cleavage site of the spike protein on SARS-CoV-2 replication and pathogenesis in the host and immune responses and vaccination. Therefore, here we specifically focused on genomic evolution and properties of the cleavage site of spike protein in the context of SARS-CoV-2 followed by its effect on viral entry, replication, and pathogenesis. We also explored whether the spike protein furin cleavage site affected the host immune responses and SARS-CoV-2 vaccination. This review will help to provide novel insights into the effects of polybasic furin cleavage site on the current COVID-19 pandemic. Twit Text FOAVip Roles of the polybasic furin cleavage site of spike protein in SARS-CoV-2 replication, pathogenesis, and host immune responses and vaccination ????J Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=34936124 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34936124 #FOAvip English Wikipedia <ref>{{Cite pmid|34936124}}</ref> Roles of the polybasic furin cleavage site of spike protein in SARS-CoV-2 replication, pathogenesis, and host immune responses and vaccination #MMPMID34936124 Hossain MG; Tang YD; Akter S; Zheng C J Med Virol 2022[May]; 94 (5): 1815-1820 PMID34936124show ga The polybasic furin cleavage site insertion with four amino acid motifs (PRRA) in spike protein's S1/S2 junction site is important in determining viral infectivity, transmission, and host range. However, there is no review so far explaining the effect of the furin cleavage site of the spike protein on SARS-CoV-2 replication and pathogenesis in the host and immune responses and vaccination. Therefore, here we specifically focused on genomic evolution and properties of the cleavage site of spike protein in the context of SARS-CoV-2 followed by its effect on viral entry, replication, and pathogenesis. We also explored whether the spike protein furin cleavage site affected the host immune responses and SARS-CoV-2 vaccination. This review will help to provide novel insights into the effects of polybasic furin cleavage site on the current COVID-19 pandemic. |*COVID-19/prevention & control[MESH] |*SARS-CoV-2/genetics[MESH] |COVID-19 Vaccines[MESH] |Furin/metabolism[MESH] |Humans[MESH] |Immunity[MESH] |Pandemics[MESH] |Spike Glycoprotein, Coronavirus/metabolism[MESH]Roles of the polybasic furin cleavage site of spike protein in SARS-Co(epmc).pdf DeepDyve Pubget Overpricing