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10.3389/fgene.2021.774916 http://scihub22266oqcxt.onion/10.3389/fgene.2021.774916 34925459!8677840!34925459     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34925459&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Genet 2021 ; 12 (ä): 774916 Nephropedia Template TP {{tp|p=34925459|t=2021. Approaching Genetics Through the MHC Lens: Tools and Methods for HLA Research |pdf=|usr=}}{{34925459}} gab.com Text Approaching Genetics Through the MHC Lens: Tools and Methods for HLA Research JO: Front Genet http://www.kidney.de/pget.php?&tw=1&pmid=34925459 #FOAvip The current SARS-CoV-2 pandemic era launched an immediate and broad response of the research community with studies both about the virus and host genetics. Research in genetics investigated HLA association with COVID-19 based on in silico, population, and individual data. However, they were conducted with variable scale and success; convincing results were mostly obtained with broader whole-genome association studies. Here, we propose a technical review of HLA analysis, including basic HLA knowledge as well as available tools and advice. We notably describe recent algorithms to infer and call HLA genotypes from GWAS SNPs and NGS data, respectively, which opens the possibility to investigate HLA from large datasets without a specific initial focus on this region. We thus hope this overview will empower geneticists who were unfamiliar with HLA to run MHC-focused analyses following the footsteps of the Covid-19|HLA & Immunogenetics Consortium. Twit Text FOAVip Approaching Genetics Through the MHC Lens: Tools and Methods for HLA Research ????Front Genet http://www.kidney.de/pget.php?&tw=1&pmid=34925459 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34925459 #FOAvip English Wikipedia <ref>{{Cite pmid|34925459}}</ref> Approaching Genetics Through the MHC Lens: Tools and Methods for HLA Research #MMPMID34925459 Douillard V; Castelli EC; Mack SJ; Hollenbach JA; Gourraud PA; Vince N; Limou S Front Genet 2021[]; 12 (ä): 774916 PMID34925459show ga The current SARS-CoV-2 pandemic era launched an immediate and broad response of the research community with studies both about the virus and host genetics. Research in genetics investigated HLA association with COVID-19 based on in silico, population, and individual data. However, they were conducted with variable scale and success; convincing results were mostly obtained with broader whole-genome association studies. Here, we propose a technical review of HLA analysis, including basic HLA knowledge as well as available tools and advice. We notably describe recent algorithms to infer and call HLA genotypes from GWAS SNPs and NGS data, respectively, which opens the possibility to investigate HLA from large datasets without a specific initial focus on this region. We thus hope this overview will empower geneticists who were unfamiliar with HLA to run MHC-focused analyses following the footsteps of the Covid-19|HLA & Immunogenetics Consortium. äApproaching Genetics Through the MHC Lens: Tools and Methods for HLA R(epmc).pdf DeepDyve Pubget Overpricing