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10.1038/s41392-021-00822-x http://scihub22266oqcxt.onion/10.1038/s41392-021-00822-x 34916489!8674414!34916489     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Signal+Transduct+Target+Ther 2021 ; 6 (1): 427 Nephropedia Template TP {{tp|p=34916489|t=2021. COVID-19 induces new-onset insulin resistance and lipid metabolic dysregulation via regulation of secreted metabolic factors |pdf=|usr=}}{{34916489}} gab.com Text COVID-19 induces new-onset insulin resistance and lipid metabolic dysregulation via regulation of secreted metabolic factors JO: Signal Transduct Target Ther http://www.kidney.de/pget.php?&tw=1&pmid=34916489 #FOAvip Abnormal glucose and lipid metabolism in COVID-19 patients were recently reported with unclear mechanism. In this study, we retrospectively investigated a cohort of COVID-19 patients without pre-existing metabolic-related diseases, and found new-onset insulin resistance, hyperglycemia, and decreased HDL-C in these patients. Mechanistically, SARS-CoV-2 infection increased the expression of RE1-silencing transcription factor (REST), which modulated the expression of secreted metabolic factors including myeloperoxidase, apelin, and myostatin at the transcriptional level, resulting in the perturbation of glucose and lipid metabolism. Furthermore, several lipids, including (+/-)5-HETE, (+/-)12-HETE, propionic acid, and isobutyric acid were identified as the potential biomarkers of COVID-19-induced metabolic dysregulation, especially in insulin resistance. Taken together, our study revealed insulin resistance as the direct cause of hyperglycemia upon COVID-19, and further illustrated the underlying mechanisms, providing potential therapeutic targets for COVID-19-induced metabolic complications. Twit Text FOAVip COVID-19 induces new-onset insulin resistance and lipid metabolic dysregulation via regulation of secreted metabolic factors ????Signal Transduct Target Ther http://www.kidney.de/pget.php?&tw=1&pmid=34916489 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34916489 #FOAvip English Wikipedia <ref>{{Cite pmid|34916489}}</ref> COVID-19 induces new-onset insulin resistance and lipid metabolic dysregulation via regulation of secreted metabolic factors #MMPMID34916489 He X; Liu C; Peng J; Li Z; Li F; Wang J; Hu A; Peng M; Huang K; Fan D; Li N; Zhang F; Cai W; Tan X; Hu Z; Deng X; Li Y; Mo X; Li L; Shi Y; Yang L; Zhu Y; Wu Y; Liang H; Liao B; Hong W; He R; Li J; Guo P; Zhuo Y; Zhao L; Hu F; Li W; Zhu W; Zhang Z; Guo Z; Zhang W; Hong X; Cai W; Gu L; Du Z; Zhang Y; Xu J; Zuo T; Deng K; Yan L; Chen X; Chen S; Lei C Signal Transduct Target Ther 2021[Dec]; 6 (1): 427 PMID34916489show ga Abnormal glucose and lipid metabolism in COVID-19 patients were recently reported with unclear mechanism. In this study, we retrospectively investigated a cohort of COVID-19 patients without pre-existing metabolic-related diseases, and found new-onset insulin resistance, hyperglycemia, and decreased HDL-C in these patients. Mechanistically, SARS-CoV-2 infection increased the expression of RE1-silencing transcription factor (REST), which modulated the expression of secreted metabolic factors including myeloperoxidase, apelin, and myostatin at the transcriptional level, resulting in the perturbation of glucose and lipid metabolism. Furthermore, several lipids, including (+/-)5-HETE, (+/-)12-HETE, propionic acid, and isobutyric acid were identified as the potential biomarkers of COVID-19-induced metabolic dysregulation, especially in insulin resistance. Taken together, our study revealed insulin resistance as the direct cause of hyperglycemia upon COVID-19, and further illustrated the underlying mechanisms, providing potential therapeutic targets for COVID-19-induced metabolic complications. |*Insulin Resistance[MESH] |*Lipid Metabolism[MESH] |Adult[MESH] |Aged[MESH] |Biomarkers/blood[MESH] |COVID-19/*blood/complications[MESH] |Female[MESH] |Humans[MESH] |Hyperglycemia/*blood/etiology[MESH] |Lipids/*blood[MESH] |Male[MESH] |Middle Aged[MESH] |Retrospective Studies[MESH]COVID-19 induces new-onset insulin resistance and lipid metabolic dysr(epmc).pdf DeepDyve Pubget Overpricing