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10.1016/j.biopha.2021.112385

http://scihub22266oqcxt.onion/10.1016/j.biopha.2021.112385
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suck abstract from ncbi


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pmid34915673      Biomed+Pharmacother 2022 ; 145 (ä): 112385
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  • Chemically modified mRNA beyond COVID-19: Potential preventive and therapeutic applications for targeting chronic diseases #MMPMID34915673
  • Elkhalifa D; Rayan M; Negmeldin AT; Elhissi A; Khalil A
  • Biomed Pharmacother 2022[Jan]; 145 (ä): 112385 PMID34915673show ga
  • Chemically modified mRNA represents a unique, efficient, and straightforward approach to produce a class of biopharmaceutical agents. It has been already approved as a vaccination-based method for targeting SARS-CoV-2 virus. The COVID-19 pandemic has highlighted the prospect of synthetic modified mRNA to efficiently and safely combat various diseases. Recently, various optimization advances have been adopted to overcome the limitations associated with conventional gene therapeutics leading to wide-ranging applications in different disease conditions. This review sheds light on emerging directions of chemically modified mRNAs to prevent and treat widespread chronic diseases, including metabolic disorders, cancer vaccination and immunotherapy, musculoskeletal disorders, respiratory conditions, cardiovascular diseases, and liver diseases.
  • |*Vaccines, Synthetic/administration & dosage/immunology[MESH]
  • |*mRNA Vaccines/administration & dosage/immunology[MESH]
  • |Biological Availability[MESH]
  • |COVID-19/*prevention & control[MESH]
  • |Chronic Disease/*prevention & control/*therapy[MESH]
  • |Drug Carriers[MESH]
  • |Forecasting[MESH]
  • |Gene Transfer Techniques[MESH]
  • |Genetic Therapy/*methods[MESH]
  • |Genetic Vectors/administration & dosage/therapeutic use[MESH]
  • |Humans[MESH]
  • |Immunotherapy, Active[MESH]
  • |Immunotherapy/*methods[MESH]
  • |Nanoparticle Drug Delivery System[MESH]
  • |Pandemics/*prevention & control[MESH]
  • |RNA Stability[MESH]
  • |RNA, Messenger/administration & dosage/*chemistry/immunology/therapeutic use[MESH]
  • |SARS-CoV-2/genetics/*immunology[MESH]


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