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10.1016/j.mvr.2021.104303

http://scihub22266oqcxt.onion/10.1016/j.mvr.2021.104303
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suck abstract from ncbi

pmid34914941      Microvasc+Res 2022 ; 140 (ä): 104303
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  • Endothelial injury in COVID-19 and septic patients #MMPMID34914941
  • Hokama LT; Veiga ADM; Menezes MCS; Sardinha Pinto AA; de Lima TM; Ariga SKK; Barbeiro HV; Barbeiro DF; de Lucena Moreira C; Stanzani G; Brandao RA; Marchini JF; Alencar JC; Marino LO; Gomez LM; Souza HP
  • Microvasc Res 2022[Mar]; 140 (ä): 104303 PMID34914941show ga
  • Systemic inflammatory response, as observed in sepsis and severe COVID-19, may lead to endothelial damage. Therefore, we aim to compare the extent of endothelial injury and its relationship to inflammation in both diseases. We included patients diagnosed with sepsis (SEPSIS group, n = 21), mild COVID-19 (MILD group, n = 31), and severe COVID-19 (SEVERE group, n = 24). Clinical and routine laboratory data were obtained, circulating cytokines (INF-gamma, TNF-alpha, and IL-10) and endothelial injury markers (E-Selectin, Tissue Factor (TF) and von Willebrand factor (vWF)) were measured. Compared to the SEPSIS group, patients with severe COVID-19 present similar clinical and laboratory data, except for lower circulating IL-10 and E-Selectin levels. Compared to the MILD group, patients in the SEVERE group showed higher levels of TNF-alpha, IL-10, and TF. There was no clear relationship between cytokines and endothelial injury markers among the three studied groups; however, in SEVERE COVID-19 patients, there is a positive relationship between INF-gamma with TF and a negative relationship between IL-10 and vWF. In conclusion, COVID-19 and septic patients have a similar pattern of cytokines and endothelial dysfunction markers. These findings highlight the importance of endothelium dysfunction in COVID-19 and suggest that endothelium should be better evaluated as a therapeutic target for the disease.
  • |*SARS-CoV-2[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Biomarkers[MESH]
  • |Blood Cell Count[MESH]
  • |C-Reactive Protein/analysis[MESH]
  • |COVID-19/blood/complications/*pathology/physiopathology[MESH]
  • |E-Selectin/blood[MESH]
  • |Endothelium, Vascular/*pathology[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Interferon-gamma/blood[MESH]
  • |Interleukin-10/blood[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Retrospective Studies[MESH]
  • |Sepsis/blood/complications/*pathology/physiopathology[MESH]
  • |Severity of Illness Index[MESH]
  • |Systemic Inflammatory Response Syndrome/*blood/etiology/physiopathology[MESH]
  • |Thromboplastin/analysis[MESH]
  • |Tumor Necrosis Factor-alpha/analysis[MESH]


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