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10.1126/sciimmunol.abl5652

http://scihub22266oqcxt.onion/10.1126/sciimmunol.abl5652
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34914544!8977051!34914544
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suck abstract from ncbi


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pmid34914544      Sci+Immunol 2022 ; 7 (68): eabl5652
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  • High-affinity, neutralizing antibodies to SARS-CoV-2 can be made without T follicular helper cells #MMPMID34914544
  • Chen JS; Chow RD; Song E; Mao T; Israelow B; Kamath K; Bozekowski J; Haynes WA; Filler RB; Menasche BL; Wei J; Alfajaro MM; Song W; Peng L; Carter L; Weinstein JS; Gowthaman U; Chen S; Craft J; Shon JC; Iwasaki A; Wilen CB; Eisenbarth SC
  • Sci Immunol 2022[Feb]; 7 (68): eabl5652 PMID34914544show ga
  • T follicular helper (T(FH)) cells are the conventional drivers of protective, germinal center (GC)-based antiviral antibody responses. However, loss of T(FH) cells and GCs has been observed in patients with severe COVID-19. As T cell-B cell interactions and immunoglobulin class switching still occur in these patients, noncanonical pathways of antibody production may be operative during SARS-CoV-2 infection. We found that both T(FH)-dependent and -independent antibodies were induced against SARS-CoV-2 infection, SARS-CoV-2 vaccination, and influenza A virus infection. Although T(FH)-independent antibodies to SARS-CoV-2 had evidence of reduced somatic hypermutation, they were still high affinity, durable, and reactive against diverse spike-derived epitopes and were capable of neutralizing both homologous SARS-CoV-2 and the B.1.351 (beta) variant of concern. We found by epitope mapping and B cell receptor sequencing that T(FH) cells focused the B cell response, and therefore, in the absence of T(FH) cells, a more diverse clonal repertoire was maintained. These data support an alternative pathway for the induction of B cell responses during viral infection that enables effective, neutralizing antibody production to complement traditional GC-derived antibodies that might compensate for GCs damaged by viral inflammation.
  • |Amino Acid Sequence[MESH]
  • |Animals[MESH]
  • |Antibodies, Neutralizing/*immunology[MESH]
  • |Antibodies, Viral/*immunology[MESH]
  • |Antibody Formation/immunology[MESH]
  • |B-Lymphocytes/immunology[MESH]
  • |COVID-19 Vaccines/immunology[MESH]
  • |COVID-19/*immunology[MESH]
  • |Germinal Center/immunology[MESH]
  • |Humans[MESH]
  • |Lymphocyte Activation/immunology[MESH]
  • |Mice[MESH]
  • |SARS-CoV-2/*immunology[MESH]
  • |T Follicular Helper Cells/*immunology[MESH]


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