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10.15252/embr.202154341 http://scihub22266oqcxt.onion/10.15252/embr.202154341 34914162!8811647!34914162     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       EMBO+Rep 2022 ; 23 (2): e54341 Nephropedia Template TP {{tp|p=34914162|t=2022. A virus-derived microRNA targets immune response genes during SARS-CoV-2 infection |pdf=|usr=}}{{34914162}} gab.com Text A virus-derived microRNA targets immune response genes during SARS-CoV-2 infection JO: EMBO Rep http://www.kidney.de/pget.php?&tw=1&pmid=34914162 #FOAvip SARS-CoV-2 infection results in impaired interferon response in patients with severe COVID-19. However, how SARS-CoV-2 interferes with host immune responses is incompletely understood. Here, we sequence small RNAs from SARS-CoV-2-infected human cells and identify a microRNA (miRNA) derived from a recently evolved region of the viral genome. We show that the virus-derived miRNA produces two miRNA isoforms in infected cells by the enzyme Dicer, which are loaded into Argonaute proteins. Moreover, the predominant miRNA isoform targets the 3'UTR of interferon-stimulated genes and represses their expression in a miRNA-like fashion. Finally, the two viral miRNA isoforms were detected in nasopharyngeal swabs from COVID-19 patients. We propose that SARS-CoV-2 can potentially employ a virus-derived miRNA to hijack the host miRNA machinery, which could help to evade the interferon-mediated immune response. Twit Text FOAVip A virus-derived microRNA targets immune response genes during SARS-CoV-2 infection ????EMBO Rep http://www.kidney.de/pget.php?&tw=1&pmid=34914162 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34914162 #FOAvip English Wikipedia <ref>{{Cite pmid|34914162}}</ref> A virus-derived microRNA targets immune response genes during SARS-CoV-2 infection #MMPMID34914162 Singh M; Chazal M; Quarato P; Bourdon L; Malabat C; Vallet T; Vignuzzi M; van der Werf S; Behillil S; Donati F; Sauvonnet N; Nigro G; Bourgine M; Jouvenet N; Cecere G EMBO Rep 2022[Feb]; 23 (2): e54341 PMID34914162show ga SARS-CoV-2 infection results in impaired interferon response in patients with severe COVID-19. However, how SARS-CoV-2 interferes with host immune responses is incompletely understood. Here, we sequence small RNAs from SARS-CoV-2-infected human cells and identify a microRNA (miRNA) derived from a recently evolved region of the viral genome. We show that the virus-derived miRNA produces two miRNA isoforms in infected cells by the enzyme Dicer, which are loaded into Argonaute proteins. Moreover, the predominant miRNA isoform targets the 3'UTR of interferon-stimulated genes and represses their expression in a miRNA-like fashion. Finally, the two viral miRNA isoforms were detected in nasopharyngeal swabs from COVID-19 patients. We propose that SARS-CoV-2 can potentially employ a virus-derived miRNA to hijack the host miRNA machinery, which could help to evade the interferon-mediated immune response. |*COVID-19/immunology[MESH] |*MicroRNAs/genetics[MESH] |3' Untranslated Regions[MESH] |Humans[MESH] |Immunity[MESH] |RNA, Viral/*genetics[MESH]A virus-derived microRNA targets immune response genes during SARS-CoV(epmc).pdf DeepDyve Pubget Overpricing