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10.1038/s41598-021-03245-4 http://scihub22266oqcxt.onion/10.1038/s41598-021-03245-4 34911967!8674272!34911967     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2021 ; 11 (1): 24042 Nephropedia Template TP {{tp|p=34911967|t=2021. SARS-CoV-2 infection reduces human nasopharyngeal commensal microbiome with inclusion of pathobionts |pdf=|usr=}}{{34911967}} gab.com Text SARS-CoV-2 infection reduces human nasopharyngeal commensal microbiome with inclusion of pathobionts JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=34911967 #FOAvip The microbiota of the nasopharyngeal tract (NT) play a role in host immunity against respiratory infectious diseases. However, scant information is available on interactions of SARS-CoV-2 with the nasopharyngeal microbiome. This study characterizes the effects of SARS-CoV-2 infection on human nasopharyngeal microbiomes and their relevant metabolic functions. Twenty-two (n = 22) nasopharyngeal swab samples (including COVID-19 patients = 8, recovered humans = 7, and healthy people = 7) were collected, and underwent to RNAseq-based metagenomic investigation. Our RNAseq data mapped to 2281 bacterial species (including 1477, 919 and 676 in healthy, COVID-19 and recovered metagenomes, respectively) indicating a distinct microbiome dysbiosis. The COVID-19 and recovered samples included 67% and 77% opportunistic bacterial species, respectively compared to healthy controls. Notably, 79% commensal bacterial species found in healthy controls were not detected in COVID-19 and recovered people. Similar dysbiosis was also found in viral and archaeal fraction of the nasopharyngeal microbiomes. We also detected several altered metabolic pathways and functional genes in the progression and pathophysiology of COVID-19. The nasopharyngeal microbiome dysbiosis and their genomic features determined by our RNAseq analyses shed light on early interactions of SARS-CoV-2 with the nasopharyngeal resident microbiota that might be helpful for developing microbiome-based diagnostics and therapeutics for this novel pandemic disease. Twit Text FOAVip SARS-CoV-2 infection reduces human nasopharyngeal commensal microbiome with inclusion of pathobionts ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=34911967 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34911967 #FOAvip English Wikipedia <ref>{{Cite pmid|34911967}}</ref> SARS-CoV-2 infection reduces human nasopharyngeal commensal microbiome with inclusion of pathobionts #MMPMID34911967 Hoque MN; Sarkar MMH; Rahman MS; Akter S; Banu TA; Goswami B; Jahan I; Hossain MS; Shamsuzzaman AKM; Nafisa T; Molla MMA; Yeasmin M; Ghosh AK; Osman E; Alam SKS; Uzzaman MS; Habib MA; Mahmud ASM; Crandall KA; Islam T; Khan MS Sci Rep 2021[Dec]; 11 (1): 24042 PMID34911967show ga The microbiota of the nasopharyngeal tract (NT) play a role in host immunity against respiratory infectious diseases. However, scant information is available on interactions of SARS-CoV-2 with the nasopharyngeal microbiome. This study characterizes the effects of SARS-CoV-2 infection on human nasopharyngeal microbiomes and their relevant metabolic functions. Twenty-two (n = 22) nasopharyngeal swab samples (including COVID-19 patients = 8, recovered humans = 7, and healthy people = 7) were collected, and underwent to RNAseq-based metagenomic investigation. Our RNAseq data mapped to 2281 bacterial species (including 1477, 919 and 676 in healthy, COVID-19 and recovered metagenomes, respectively) indicating a distinct microbiome dysbiosis. The COVID-19 and recovered samples included 67% and 77% opportunistic bacterial species, respectively compared to healthy controls. Notably, 79% commensal bacterial species found in healthy controls were not detected in COVID-19 and recovered people. Similar dysbiosis was also found in viral and archaeal fraction of the nasopharyngeal microbiomes. We also detected several altered metabolic pathways and functional genes in the progression and pathophysiology of COVID-19. The nasopharyngeal microbiome dysbiosis and their genomic features determined by our RNAseq analyses shed light on early interactions of SARS-CoV-2 with the nasopharyngeal resident microbiota that might be helpful for developing microbiome-based diagnostics and therapeutics for this novel pandemic disease. |Adult[MESH] |Aged[MESH] |Bacteria/*classification/genetics/isolation & purification/pathogenicity[MESH] |COVID-19/*microbiology[MESH] |Case-Control Studies[MESH] |Female[MESH] |High-Throughput Nucleotide Sequencing[MESH] |Humans[MESH] |Male[MESH] |Metagenomics[MESH] |Middle Aged[MESH] |Nasopharynx/*microbiology[MESH] |Phylogeny[MESH] |SARS-CoV-2/*genetics[MESH] |Sequence Analysis, RNA/*methods[MESH] |Symbiosis[MESH]SARS-CoV-2 infection reduces human nasopharyngeal commensal microbiome(epmc).pdf DeepDyve Pubget Overpricing