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  • Antigenic drift: Understanding COVID-19 #MMPMID34910934
  • Yewdell JW
  • Immunity 2021[Dec]; 54 (12): 2681-2687 PMID34910934show ga
  • Antigenic drift refers to the evolutionary accumulation of amino acid substitutions in viral proteins selected by host adaptive immune systems as the virus circulates in a population. Antigenic drift can substantially limit the duration of immunity conferred by infection and vaccination. Here, I explain the factors contributing to the rapid antigenic drift of the SARS-CoV-2 spike protein and receptor proteins of other viruses and discuss the implications for SARS-CoV-2 evolution and immunity.
  • |Adaptive Immunity[MESH]
  • |Animals[MESH]
  • |Antigenic Drift and Shift[MESH]
  • |Biological Evolution[MESH]
  • |COVID-19/*immunology[MESH]
  • |Host-Pathogen Interactions[MESH]
  • |Humans[MESH]
  • |Mutation/*genetics[MESH]
  • |SARS-CoV-2/*physiology[MESH]
  • |Spike Glycoprotein, Coronavirus/immunology[MESH]
  • |Vaccination[MESH]

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  • suck abstract from ncbi

    2681 12.54 2021