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10.1093/nar/gkab1226 http://scihub22266oqcxt.onion/10.1093/nar/gkab1226 34908151!8789046!34908151     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34908151&cmd=llinks): Failed to open stream: HTTP request failed! 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Highly conserved s2m element of SARS-CoV-2 dimerizes via a kissing complex and interacts with host miRNA-1307-3p |pdf=|usr=}}{{34908151}} gab.com Text Highly conserved s2m element of SARS-CoV-2 dimerizes via a kissing complex and interacts with host miRNA-1307-3p JO: Nucleic Acids Res http://www.kidney.de/pget.php?&tw=1&pmid=34908151 #FOAvip The ongoing COVID-19 pandemic highlights the necessity for a more fundamental understanding of the coronavirus life cycle. The causative agent of the disease, SARS-CoV-2, is being studied extensively from a structural standpoint in order to gain insight into key molecular mechanisms required for its survival. Contained within the untranslated regions of the SARS-CoV-2 genome are various conserved stem-loop elements that are believed to function in RNA replication, viral protein translation, and discontinuous transcription. While the majority of these regions are variable in sequence, a 41-nucleotide s2m element within the genome 3' untranslated region is highly conserved among coronaviruses and three other viral families. In this study, we demonstrate that the SARS-CoV-2 s2m element dimerizes by forming an intermediate homodimeric kissing complex structure that is subsequently converted to a thermodynamically stable duplex conformation. This process is aided by the viral nucleocapsid protein, potentially indicating a role in mediating genome dimerization. Furthermore, we demonstrate that the s2m element interacts with multiple copies of host cellular microRNA (miRNA) 1307-3p. Taken together, our results highlight the potential significance of the dimer structures formed by the s2m element in key biological processes and implicate the motif as a possible therapeutic drug target for COVID-19 and other coronavirus-related diseases. Twit Text FOAVip Highly conserved s2m element of SARS-CoV-2 dimerizes via a kissing complex and interacts with host miRNA-1307-3p ????Nucleic Acids Res http://www.kidney.de/pget.php?&tw=1&pmid=34908151 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34908151 #FOAvip English Wikipedia <ref>{{Cite pmid|34908151}}</ref> Highly conserved s2m element of SARS-CoV-2 dimerizes via a kissing complex and interacts with host miRNA-1307-3p #MMPMID34908151 Imperatore JA; Cunningham CL; Pellegrene KA; Brinson RG; Marino JP; Evanseck JD; Mihailescu MR Nucleic Acids Res 2022[Jan]; 50 (2): 1017-1032 PMID34908151show ga The ongoing COVID-19 pandemic highlights the necessity for a more fundamental understanding of the coronavirus life cycle. The causative agent of the disease, SARS-CoV-2, is being studied extensively from a structural standpoint in order to gain insight into key molecular mechanisms required for its survival. Contained within the untranslated regions of the SARS-CoV-2 genome are various conserved stem-loop elements that are believed to function in RNA replication, viral protein translation, and discontinuous transcription. While the majority of these regions are variable in sequence, a 41-nucleotide s2m element within the genome 3' untranslated region is highly conserved among coronaviruses and three other viral families. In this study, we demonstrate that the SARS-CoV-2 s2m element dimerizes by forming an intermediate homodimeric kissing complex structure that is subsequently converted to a thermodynamically stable duplex conformation. This process is aided by the viral nucleocapsid protein, potentially indicating a role in mediating genome dimerization. Furthermore, we demonstrate that the s2m element interacts with multiple copies of host cellular microRNA (miRNA) 1307-3p. Taken together, our results highlight the potential significance of the dimer structures formed by the s2m element in key biological processes and implicate the motif as a possible therapeutic drug target for COVID-19 and other coronavirus-related diseases. |3' Untranslated Regions/*genetics[MESH] |Base Sequence[MESH] |Binding Sites/genetics[MESH] |COVID-19/*genetics/metabolism/virology[MESH] |Conserved Sequence/genetics[MESH] |Dimerization[MESH] |Genome, Viral/genetics[MESH] |Host-Pathogen Interactions/genetics[MESH] |Humans[MESH] |MicroRNAs/*genetics/metabolism[MESH] |Nucleic Acid Conformation[MESH] |Nucleotide Motifs/*genetics[MESH] |Proton Magnetic Resonance Spectroscopy/methods[MESH] |RNA, Viral/chemistry/*genetics/metabolism[MESH]Highly conserved s2m element of SARS-CoV-2 dimerizes via a kissing com(epmc).pdf DeepDyve Pubget Overpricing