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10.1073/pnas.2110455118 http://scihub22266oqcxt.onion/10.1073/pnas.2110455118 34907015!8713789!34907015     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2021 ; 118 (51): ä Nephropedia Template TP {{tp|p=34907015|t=2021. Large-scale genomic study reveals robust activation of the immune system following advanced Inner Engineering meditation retreat |pdf=|usr=}}{{34907015}} gab.com Text Large-scale genomic study reveals robust activation of the immune system following advanced Inner Engineering meditation retreat JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=34907015 #FOAvip The positive impact of meditation on human well-being is well documented, yet its molecular mechanisms are incompletely understood. We applied a comprehensive systems biology approach starting with whole-blood gene expression profiling combined with multilevel bioinformatic analyses to characterize the coexpression, transcriptional, and protein-protein interaction networks to identify a meditation-specific core network after an advanced 8-d Inner Engineering retreat program. We found the response to oxidative stress, detoxification, and cell cycle regulation pathways were down-regulated after meditation. Strikingly, 220 genes directly associated with immune response, including 68 genes related to interferon signaling, were up-regulated, with no significant expression changes in the inflammatory genes. This robust meditation-specific immune response network is significantly dysregulated in multiple sclerosis and severe COVID-19 patients. The work provides a foundation for understanding the effect of meditation and suggests that meditation as a behavioral intervention can voluntarily and nonpharmacologically improve the immune response for treating various conditions associated with excessive or persistent inflammation with a dampened immune system profile. Twit Text FOAVip Large-scale genomic study reveals robust activation of the immune system following advanced Inner Engineering meditation retreat ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=34907015 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34907015 #FOAvip English Wikipedia <ref>{{Cite pmid|34907015}}</ref> Large-scale genomic study reveals robust activation of the immune system following advanced Inner Engineering meditation retreat #MMPMID34907015 Chandran V; Bermudez ML; Koka M; Chandran B; Pawale D; Vishnubhotla R; Alankar S; Maturi R; Subramaniam B; Sadhasivam S Proc Natl Acad Sci U S A 2021[Dec]; 118 (51): ä PMID34907015show ga The positive impact of meditation on human well-being is well documented, yet its molecular mechanisms are incompletely understood. We applied a comprehensive systems biology approach starting with whole-blood gene expression profiling combined with multilevel bioinformatic analyses to characterize the coexpression, transcriptional, and protein-protein interaction networks to identify a meditation-specific core network after an advanced 8-d Inner Engineering retreat program. We found the response to oxidative stress, detoxification, and cell cycle regulation pathways were down-regulated after meditation. Strikingly, 220 genes directly associated with immune response, including 68 genes related to interferon signaling, were up-regulated, with no significant expression changes in the inflammatory genes. This robust meditation-specific immune response network is significantly dysregulated in multiple sclerosis and severe COVID-19 patients. The work provides a foundation for understanding the effect of meditation and suggests that meditation as a behavioral intervention can voluntarily and nonpharmacologically improve the immune response for treating various conditions associated with excessive or persistent inflammation with a dampened immune system profile. |*Meditation[MESH] |*Transcriptome[MESH] |Adult[MESH] |COVID-19/immunology/metabolism[MESH] |Diet, Vegan[MESH] |Female[MESH] |Genome, Human[MESH] |Humans[MESH] |Immune System/*metabolism[MESH] |Male[MESH] |Multiple Sclerosis/immunology/metabolism[MESH]Large-scale genomic study reveals robust activation of the immune syst(epmc).pdf DeepDyve Pubget Overpricing