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  • Large-scale genomic study reveals robust activation of the immune system following advanced Inner Engineering meditation retreat #MMPMID34907015
  • Chandran V; Bermudez ML; Koka M; Chandran B; Pawale D; Vishnubhotla R; Alankar S; Maturi R; Subramaniam B; Sadhasivam S
  • Proc Natl Acad Sci U S A 2021[Dec]; 118 (51): ä PMID34907015show ga
  • The positive impact of meditation on human well-being is well documented, yet its molecular mechanisms are incompletely understood. We applied a comprehensive systems biology approach starting with whole-blood gene expression profiling combined with multilevel bioinformatic analyses to characterize the coexpression, transcriptional, and protein-protein interaction networks to identify a meditation-specific core network after an advanced 8-d Inner Engineering retreat program. We found the response to oxidative stress, detoxification, and cell cycle regulation pathways were down-regulated after meditation. Strikingly, 220 genes directly associated with immune response, including 68 genes related to interferon signaling, were up-regulated, with no significant expression changes in the inflammatory genes. This robust meditation-specific immune response network is significantly dysregulated in multiple sclerosis and severe COVID-19 patients. The work provides a foundation for understanding the effect of meditation and suggests that meditation as a behavioral intervention can voluntarily and nonpharmacologically improve the immune response for treating various conditions associated with excessive or persistent inflammation with a dampened immune system profile.
  • |*Meditation[MESH]
  • |*Transcriptome[MESH]
  • |Adult[MESH]
  • |COVID-19/immunology/metabolism[MESH]
  • |Diet, Vegan[MESH]
  • |Female[MESH]
  • |Genome, Human[MESH]
  • |Humans[MESH]
  • |Immune System/*metabolism[MESH]
  • |Male[MESH]
  • |Multiple Sclerosis/immunology/metabolism[MESH]
  • |Protein Interaction Maps[MESH]

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  • suck abstract from ncbi

    ä 51.118 2021